LLM-agent - 2025-03-08

Quantifying the Reasoning Abilities of LLMs on Real-world Clinical Cases

Authors:Pengcheng Qiu, Chaoyi Wu, Shuyu Liu, Weike Zhao, Ya Zhang, Yanfeng Wang, Weidi Xie
Date:2025-03-06 18:35:39

The latest reasoning-enhanced large language models (reasoning LLMs), such as DeepSeek-R1 and OpenAI-o3, have demonstrated remarkable success. However, the application of such reasoning enhancements to the highly professional medical domain has not been clearly evaluated, particularly regarding with not only assessing the final generation but also examining the quality of their reasoning processes. In this study, we present MedR-Bench, a reasoning-focused medical evaluation benchmark comprising 1,453 structured patient cases with reasoning references mined from case reports. Our benchmark spans 13 body systems and 10 specialty disorders, encompassing both common and rare diseases. In our evaluation, we introduce a versatile framework consisting of three critical clinical stages: assessment recommendation, diagnostic decision-making, and treatment planning, comprehensively capturing the LLMs' performance across the entire patient journey in healthcare. For metrics, we propose a novel agentic system, Reasoning Evaluator, designed to automate and objectively quantify free-text reasoning responses in a scalable manner from the perspectives of efficiency, factuality, and completeness by dynamically searching and performing cross-referencing checks. As a result, we assess five state-of-the-art reasoning LLMs, including DeepSeek-R1, OpenAI-o3-mini, and others. Our results reveal that current LLMs can handle relatively simple diagnostic tasks with sufficient critical assessment results, achieving accuracy generally over 85%. However, they still struggle with more complex tasks, such as assessment recommendation and treatment planning. In reasoning, their reasoning processes are generally reliable, with factuality scores exceeding 90%, though they often omit critical reasoning steps. Our study clearly reveals further development directions for current clinical LLMs.

SurveyForge: On the Outline Heuristics, Memory-Driven Generation, and Multi-dimensional Evaluation for Automated Survey Writing

Authors:Xiangchao Yan, Shiyang Feng, Jiakang Yuan, Renqiu Xia, Bin Wang, Bo Zhang, Lei Bai
Date:2025-03-06 17:15:48

Survey paper plays a crucial role in scientific research, especially given the rapid growth of research publications. Recently, researchers have begun using LLMs to automate survey generation for better efficiency. However, the quality gap between LLM-generated surveys and those written by human remains significant, particularly in terms of outline quality and citation accuracy. To close these gaps, we introduce SurveyForge, which first generates the outline by analyzing the logical structure of human-written outlines and referring to the retrieved domain-related articles. Subsequently, leveraging high-quality papers retrieved from memory by our scholar navigation agent, SurveyForge can automatically generate and refine the content of the generated article. Moreover, to achieve a comprehensive evaluation, we construct SurveyBench, which includes 100 human-written survey papers for win-rate comparison and assesses AI-generated survey papers across three dimensions: reference, outline, and content quality. Experiments demonstrate that SurveyForge can outperform previous works such as AutoSurvey.

The Next Frontier of LLM Applications: Open Ecosystems and Hardware Synergy

Authors:Xinyi Hou, Yanjie Zhao, Haoyu Wang
Date:2025-03-06 16:38:23

Large Language Model (LLM) applications, including LLM app stores and autonomous agents, are shaping the future of AI ecosystems. However, platform silos, fragmented hardware integration, and the absence of standardized interfaces limit scalability, interoperability, and resource efficiency. While LLM app stores democratize AI, their closed ecosystems restrict modular AI reuse and cross-platform portability. Meanwhile, agent-based frameworks offer flexibility but often lack seamless integration across diverse environments. This paper envisions the future of LLM applications and proposes a three-layer decoupled architecture grounded in software engineering principles such as layered system design, service-oriented architectures, and hardware-software co-design. This architecture separates application logic, communication protocols, and hardware execution, enhancing modularity, efficiency, and cross-platform compatibility. Beyond architecture, we highlight key security and privacy challenges for safe, scalable AI deployment and outline research directions in software and security engineering. This vision aims to foster open, secure, and interoperable LLM ecosystems, guiding future advancements in AI applications.

ToolFuzz -- Automated Agent Tool Testing

Authors:Ivan Milev, Mislav Balunović, Maximilian Baader, Martin Vechev
Date:2025-03-06 14:29:52

Large Language Model (LLM) Agents leverage the advanced reasoning capabilities of LLMs in real-world applications. To interface with an environment, these agents often rely on tools, such as web search or database APIs. As the agent provides the LLM with tool documentation along the user query, the completeness and correctness of this documentation is critical. However, tool documentation is often over-, under-, or ill-specified, impeding the agent's accuracy. Standard software testing approaches struggle to identify these errors as they are expressed in natural language. Thus, despite its importance, there currently exists no automated method to test the tool documentation for agents. To address this issue, we present ToolFuzz, the first method for automated testing of tool documentations. ToolFuzz is designed to discover two types of errors: (1) user queries leading to tool runtime errors and (2) user queries that lead to incorrect agent responses. ToolFuzz can generate a large and diverse set of natural inputs, effectively finding tool description errors at a low false positive rate. Further, we present two straightforward prompt-engineering approaches. We evaluate all three tool testing approaches on 32 common LangChain tools and 35 newly created custom tools and 2 novel benchmarks to further strengthen the assessment. We find that many publicly available tools suffer from underspecification. Specifically, we show that ToolFuzz identifies 20x more erroneous inputs compared to the prompt-engineering approaches, making it a key component for building reliable AI agents.

AgentSafe: Safeguarding Large Language Model-based Multi-agent Systems via Hierarchical Data Management

Authors:Junyuan Mao, Fanci Meng, Yifan Duan, Miao Yu, Xiaojun Jia, Junfeng Fang, Yuxuan Liang, Kun Wang, Qingsong Wen
Date:2025-03-06 12:41:54

Large Language Model based multi-agent systems are revolutionizing autonomous communication and collaboration, yet they remain vulnerable to security threats like unauthorized access and data breaches. To address this, we introduce AgentSafe, a novel framework that enhances MAS security through hierarchical information management and memory protection. AgentSafe classifies information by security levels, restricting sensitive data access to authorized agents. AgentSafe incorporates two components: ThreatSieve, which secures communication by verifying information authority and preventing impersonation, and HierarCache, an adaptive memory management system that defends against unauthorized access and malicious poisoning, representing the first systematic defense for agent memory. Experiments across various LLMs show that AgentSafe significantly boosts system resilience, achieving defense success rates above 80% under adversarial conditions. Additionally, AgentSafe demonstrates scalability, maintaining robust performance as agent numbers and information complexity grow. Results underscore effectiveness of AgentSafe in securing MAS and its potential for real-world application.

Towards Autonomous Reinforcement Learning for Real-World Robotic Manipulation with Large Language Models

Authors:Niccolò Turcato, Matteo Iovino, Aris Synodinos, Alberto Dalla Libera, Ruggero Carli, Pietro Falco
Date:2025-03-06 10:08:44

Recent advancements in Large Language Models (LLMs) and Visual Language Models (VLMs) have significantly impacted robotics, enabling high-level semantic motion planning applications. Reinforcement Learning (RL), a complementary paradigm, enables agents to autonomously optimize complex behaviors through interaction and reward signals. However, designing effective reward functions for RL remains challenging, especially in real-world tasks where sparse rewards are insufficient and dense rewards require elaborate design. In this work, we propose Autonomous Reinforcement learning for Complex HumanInformed Environments (ARCHIE), an unsupervised pipeline leveraging GPT-4, a pre-trained LLM, to generate reward functions directly from natural language task descriptions. The rewards are used to train RL agents in simulated environments, where we formalize the reward generation process to enhance feasibility. Additionally, GPT-4 automates the coding of task success criteria, creating a fully automated, one-shot procedure for translating human-readable text into deployable robot skills. Our approach is validated through extensive simulated experiments on single-arm and bi-manual manipulation tasks using an ABB YuMi collaborative robot, highlighting its practicality and effectiveness. Tasks are demonstrated on the real robot setup.

Measuring temporal effects of agent knowledge by date-controlled tool use

Authors:R. Patrick Xian, Qiming Cui, Stefan Bauer, Reza Abbasi-Asl
Date:2025-03-06 08:03:51

Temporal progression is an integral part of knowledge accumulation and update. Web search is frequently adopted as grounding for agent knowledge, yet its inappropriate configuration affects the quality of agent responses. Here, we construct a tool-based out-of-sample testing framework to measure the knowledge variability of large language model (LLM) agents from distinct date-controlled tools (DCTs). We demonstrate the temporal effects of an LLM agent as a writing assistant, which can use web search to help complete scientific publication abstracts. We show that temporal effects of the search engine translates into tool-dependent agent performance but can be alleviated with base model choice and explicit reasoning instructions such as chain-of-thought prompting. Our results indicate that agent evaluation should take a dynamical view and account for the temporal influence of tools and the updates of external resources.

KidneyTalk-open: No-code Deployment of a Private Large Language Model with Medical Documentation-Enhanced Knowledge Database for Kidney Disease

Authors:Yongchao Long, Chao Yang, Gongzheng Tang, Jinwei Wang, Zhun Sui, Yuxi Zhou, Shenda Hong, Luxia Zhang
Date:2025-03-06 07:01:36

Privacy-preserving medical decision support for kidney disease requires localized deployment of large language models (LLMs) while maintaining clinical reasoning capabilities. Current solutions face three challenges: 1) Cloud-based LLMs pose data security risks; 2) Local model deployment demands technical expertise; 3) General LLMs lack mechanisms to integrate medical knowledge. Retrieval-augmented systems also struggle with medical document processing and clinical usability. We developed KidneyTalk-open, a desktop system integrating three technical components: 1) No-code deployment of state-of-the-art (SOTA) open-source LLMs (such as DeepSeek-r1, Qwen2.5) via local inference engine; 2) Medical document processing pipeline combining context-aware chunking and intelligent filtering; 3) Adaptive Retrieval and Augmentation Pipeline (AddRep) employing agents collaboration for improving the recall rate of medical documents. A graphical interface was designed to enable clinicians to manage medical documents and conduct AI-powered consultations without technical expertise. Experimental validation on 1,455 challenging nephrology exam questions demonstrates AddRep's effectiveness: achieving 29.1% accuracy (+8.1% over baseline) with intelligent knowledge integration, while maintaining robustness through 4.9% rejection rate to suppress hallucinations. Comparative case studies with the mainstream products (AnythingLLM, Chatbox, GPT4ALL) demonstrate KidneyTalk-open's superior performance in real clinical query. KidneyTalk-open represents the first no-code medical LLM system enabling secure documentation-enhanced medical Q&A on desktop. Its designs establishes a new framework for privacy-sensitive clinical AI applications. The system significantly lowers technical barriers while improving evidence traceability, enabling more medical staff or patients to use SOTA open-source LLMs conveniently.

Dynamic Benchmarking of Reasoning Capabilities in Code Large Language Models Under Data Contamination

Authors:Simin Chen, Pranav Pusarla, Baishakhi Ray
Date:2025-03-06 06:56:59

The rapid evolution of code largelanguage models underscores the need for effective and transparent benchmarking of their reasoning capabilities. However, the current benchmarking approach heavily depends on publicly available, human-created datasets. The widespread use of these fixed benchmark datasets makes the benchmarking process to be static and thus particularly susceptible to data contamination, an unavoidable consequence of the extensive data collection processes used to train Code LLMs. Existing approaches that address data contamination often suffer from human effort limitations and imbalanced problem complexity. To tackle these challenges, we propose \tool, a novel benchmarking suite for evaluating Code LLMs under potential data contamination. Given a seed programming problem, \tool employs multiple agents to extract and modify the context without altering the core logic, generating semantically equivalent variations. We introduce a dynamic data generation methods and conduct empirical studies on two seed datasets across 21 Code LLMs. Results show that \tool effectively benchmarks reasoning capabilities under contamination risks while generating diverse problem sets to ensure consistent and reliable evaluations.

InterChat: Enhancing Generative Visual Analytics using Multimodal Interactions

Authors:Juntong Chen, Jiang Wu, Jiajing Guo, Vikram Mohanty, Xueming Li, Jorge Piazentin Ono, Wenbin He, Liu Ren, Dongyu Liu
Date:2025-03-06 05:35:19

The rise of Large Language Models (LLMs) and generative visual analytics systems has transformed data-driven insights, yet significant challenges persist in accurately interpreting users' analytical and interaction intents. While language inputs offer flexibility, they often lack precision, making the expression of complex intents inefficient, error-prone, and time-intensive. To address these limitations, we investigate the design space of multimodal interactions for generative visual analytics through a literature review and pilot brainstorming sessions. Building on these insights, we introduce a highly extensible workflow that integrates multiple LLM agents for intent inference and visualization generation. We develop InterChat, a generative visual analytics system that combines direct manipulation of visual elements with natural language inputs. This integration enables precise intent communication and supports progressive, visually driven exploratory data analyses. By employing effective prompt engineering, and contextual interaction linking, alongside intuitive visualization and interaction designs, InterChat bridges the gap between user interactions and LLM-driven visualizations, enhancing both interpretability and usability. Extensive evaluations, including two usage scenarios, a user study, and expert feedback, demonstrate the effectiveness of InterChat. Results show significant improvements in the accuracy and efficiency of handling complex visual analytics tasks, highlighting the potential of multimodal interactions to redefine user engagement and analytical depth in generative visual analytics.

PokéChamp: an Expert-level Minimax Language Agent

Authors:Seth Karten, Andy Luu Nguyen, Chi Jin
Date:2025-03-06 05:06:27

We introduce Pok\'eChamp, a minimax agent powered by Large Language Models (LLMs) for Pok\'emon battles. Built on a general framework for two-player competitive games, Pok\'eChamp leverages the generalist capabilities of LLMs to enhance minimax tree search. Specifically, LLMs replace three key modules: (1) player action sampling, (2) opponent modeling, and (3) value function estimation, enabling the agent to effectively utilize gameplay history and human knowledge to reduce the search space and address partial observability. Notably, our framework requires no additional LLM training. We evaluate Pok\'eChamp in the popular Gen 9 OU format. When powered by GPT-4o, it achieves a win rate of 76% against the best existing LLM-based bot and 84% against the strongest rule-based bot, demonstrating its superior performance. Even with an open-source 8-billion-parameter Llama 3.1 model, Pok\'eChamp consistently outperforms the previous best LLM-based bot, Pok\'ellmon powered by GPT-4o, with a 64% win rate. Pok\'eChamp attains a projected Elo of 1300-1500 on the Pok\'emon Showdown online ladder, placing it among the top 30%-10% of human players. In addition, this work compiles the largest real-player Pok\'emon battle dataset, featuring over 3 million games, including more than 500k high-Elo matches. Based on this dataset, we establish a series of battle benchmarks and puzzles to evaluate specific battling skills. We further provide key updates to the local game engine. We hope this work fosters further research that leverage Pok\'emon battle as benchmark to integrate LLM technologies with game-theoretic algorithms addressing general multiagent problems. Videos, code, and dataset available at https://sites.google.com/view/pokechamp-llm.

Pretrained LLMs as Real-Time Controllers for Robot Operated Serial Production Line

Authors:Muhammad Waseem, Kshitij Bhatta, Chen Li, Qing Chang
Date:2025-03-05 20:43:49

The manufacturing industry is undergoing a transformative shift, driven by cutting-edge technologies like 5G, AI, and cloud computing. Despite these advancements, effective system control, which is crucial for optimizing production efficiency, remains a complex challenge due to the intricate, knowledge-dependent nature of manufacturing processes and the reliance on domain-specific expertise. Conventional control methods often demand heavy customization, considerable computational resources, and lack transparency in decision-making. In this work, we investigate the feasibility of using Large Language Models (LLMs), particularly GPT-4, as a straightforward, adaptable solution for controlling manufacturing systems, specifically, mobile robot scheduling. We introduce an LLM-based control framework to assign mobile robots to different machines in robot assisted serial production lines, evaluating its performance in terms of system throughput. Our proposed framework outperforms traditional scheduling approaches such as First-Come-First-Served (FCFS), Shortest Processing Time (SPT), and Longest Processing Time (LPT). While it achieves performance that is on par with state-of-the-art methods like Multi-Agent Reinforcement Learning (MARL), it offers a distinct advantage by delivering comparable throughput without the need for extensive retraining. These results suggest that the proposed LLM-based solution is well-suited for scenarios where technical expertise, computational resources, and financial investment are limited, while decision transparency and system scalability are critical concerns.

The MASK Benchmark: Disentangling Honesty From Accuracy in AI Systems

Authors:Richard Ren, Arunim Agarwal, Mantas Mazeika, Cristina Menghini, Robert Vacareanu, Brad Kenstler, Mick Yang, Isabelle Barrass, Alice Gatti, Xuwang Yin, Eduardo Trevino, Matias Geralnik, Adam Khoja, Dean Lee, Summer Yue, Dan Hendrycks
Date:2025-03-05 18:59:23

As large language models (LLMs) become more capable and agentic, the requirement for trust in their outputs grows significantly, yet at the same time concerns have been mounting that models may learn to lie in pursuit of their goals. To address these concerns, a body of work has emerged around the notion of "honesty" in LLMs, along with interventions aimed at mitigating deceptive behaviors. However, evaluations of honesty are currently highly limited, with no benchmark combining large scale and applicability to all models. Moreover, many benchmarks claiming to measure honesty in fact simply measure accuracy--the correctness of a model's beliefs--in disguise. In this work, we introduce a large-scale human-collected dataset for measuring honesty directly, allowing us to disentangle accuracy from honesty for the first time. Across a diverse set of LLMs, we find that while larger models obtain higher accuracy on our benchmark, they do not become more honest. Surprisingly, while most frontier LLMs obtain high scores on truthfulness benchmarks, we find a substantial propensity in frontier LLMs to lie when pressured to do so, resulting in low honesty scores on our benchmark. We find that simple methods, such as representation engineering interventions, can improve honesty. These results underscore the growing need for robust evaluations and effective interventions to ensure LLMs remain trustworthy.

A Practical Memory Injection Attack against LLM Agents

Authors:Shen Dong, Shaocheng Xu, Pengfei He, Yige Li, Jiliang Tang, Tianming Liu, Hui Liu, Zhen Xiang
Date:2025-03-05 17:53:24

Agents based on large language models (LLMs) have demonstrated strong capabilities in a wide range of complex, real-world applications. However, LLM agents with a compromised memory bank may easily produce harmful outputs when the past records retrieved for demonstration are malicious. In this paper, we propose a novel Memory INJection Attack, MINJA, that enables the injection of malicious records into the memory bank by only interacting with the agent via queries and output observations. These malicious records are designed to elicit a sequence of malicious reasoning steps leading to undesirable agent actions when executing the victim user's query. Specifically, we introduce a sequence of bridging steps to link the victim query to the malicious reasoning steps. During the injection of the malicious record, we propose an indication prompt to guide the agent to autonomously generate our designed bridging steps. We also propose a progressive shortening strategy that gradually removes the indication prompt, such that the malicious record will be easily retrieved when processing the victim query comes after. Our extensive experiments across diverse agents demonstrate the effectiveness of MINJA in compromising agent memory. With minimal requirements for execution, MINJA enables any user to influence agent memory, highlighting practical risks of LLM agents.

MAS-GPT: Training LLMs to Build LLM-based Multi-Agent Systems

Authors:Rui Ye, Shuo Tang, Rui Ge, Yaxin Du, Zhenfei Yin, Siheng Chen, Jing Shao
Date:2025-03-05 17:27:59

LLM-based multi-agent systems (MAS) have shown significant potential in tackling diverse tasks. However, to design effective MAS, existing approaches heavily rely on manual configurations or multiple calls of advanced LLMs, resulting in inadaptability and high inference costs. In this paper, we simplify the process of building an MAS by reframing it as a generative language task, where the input is a user query and the output is a corresponding MAS. To address this novel task, we unify the representation of MAS as executable code and propose a consistency-oriented data construction pipeline to create a high-quality dataset comprising coherent and consistent query-MAS pairs. Using this dataset, we train MAS-GPT, an open-source medium-sized LLM that is capable of generating query-adaptive MAS within a single LLM inference. The generated MAS can be seamlessly applied to process user queries and deliver high-quality responses. Extensive experiments on 9 benchmarks and 5 LLMs show that the proposed MAS-GPT consistently outperforms 10+ baseline MAS methods on diverse settings, indicating MAS-GPT's high effectiveness, efficiency and strong generalization ability. Code will be available at https://github.com/rui-ye/MAS-GPT.

Multi-Agent Systems Powered by Large Language Models: Applications in Swarm Intelligence

Authors:Cristian Jimenez-Romero, Alper Yegenoglu, Christian Blum
Date:2025-03-05 17:13:27

This work examines the integration of large language models (LLMs) into multi-agent simulations by replacing the hard-coded programs of agents with LLM-driven prompts. The proposed approach is showcased in the context of two examples of complex systems from the field of swarm intelligence: ant colony foraging and bird flocking. Central to this study is a toolchain that integrates LLMs with the NetLogo simulation platform, leveraging its Python extension to enable communication with GPT-4o via the OpenAI API. This toolchain facilitates prompt-driven behavior generation, allowing agents to respond adaptively to environmental data. For both example applications mentioned above, we employ both structured, rule-based prompts and autonomous, knowledge-driven prompts. Our work demonstrates how this toolchain enables LLMs to study self-organizing processes and induce emergent behaviors within multi-agent environments, paving the way for new approaches to exploring intelligent systems and modeling swarm intelligence inspired by natural phenomena. We provide the code, including simulation files and data at https://github.com/crjimene/swarm_gpt.

Attentive Reasoning Queries: A Systematic Method for Optimizing Instruction-Following in Large Language Models

Authors:Bar Karov, Dor Zohar, Yam Marcovitz
Date:2025-03-05 17:03:48

We present Attentive Reasoning Queries (ARQs), a novel structured reasoning approach that significantly improves instruction-following in Large Language Models through domain-specialized reasoning blueprints. While LLMs demonstrate remarkable capabilities across diverse tasks, they often fail to maintain adherence to complex, use-case-specific instructions during multi-turn conversations, presenting challenges for business-critical applications. ARQs address this limitation by guiding LLMs through systematic reasoning steps with targeted queries that reinstate critical instructions and facilitate intermediate reasoning throughout the completion process. In extensive testing within Parlant, our framework for reliable customer-facing agents in which ARQs were born out of necessity, they achieved a 90.2% success rate across 87 test scenarios, outperforming both Chain-of-Thought reasoning (86.1%) and direct response generation (81.5%). ARQs showed particular strength in addressing persistent failure modes like guideline re-application and hallucination prevention. Our analysis also revealed that ARQs can potentially be more computationally efficient than free-form reasoning when carefully designed. These findings demonstrate that structured reasoning approaches provide effective mechanisms for controlling how LLMs process information and make decisions in complex scenarios.

Benchmarking LLMs and LLM-based Agents in Practical Vulnerability Detection for Code Repositories

Authors:Alperen Yildiz, Sin G. Teo, Yiling Lou, Yebo Feng, Chong Wang, Dinil M. Divakaran
Date:2025-03-05 15:22:24

Large Language Models (LLMs) have shown promise in software vulnerability detection, particularly on function-level benchmarks like Devign and BigVul. However, real-world detection requires interprocedural analysis, as vulnerabilities often emerge through multi-hop function calls rather than isolated functions. While repository-level benchmarks like ReposVul and VulEval introduce interprocedural context, they remain computationally expensive, lack pairwise evaluation of vulnerability fixes, and explore limited context retrieval, limiting their practicality. We introduce JitVul, a JIT vulnerability detection benchmark linking each function to its vulnerability-introducing and fixing commits. Built from 879 CVEs spanning 91 vulnerability types, JitVul enables comprehensive evaluation of detection capabilities. Our results show that ReAct Agents, leveraging thought-action-observation and interprocedural context, perform better than LLMs in distinguishing vulnerable from benign code. While prompting strategies like Chain-of-Thought help LLMs, ReAct Agents require further refinement. Both methods show inconsistencies, either misidentifying vulnerabilities or over-analyzing security guards, indicating significant room for improvement.

Human Implicit Preference-Based Policy Fine-tuning for Multi-Agent Reinforcement Learning in USV Swarm

Authors:Hyeonjun Kim, Kanghoon Lee, Junho Park, Jiachen Li, Jinkyoo Park
Date:2025-03-05 14:33:18

Multi-Agent Reinforcement Learning (MARL) has shown promise in solving complex problems involving cooperation and competition among agents, such as an Unmanned Surface Vehicle (USV) swarm used in search and rescue, surveillance, and vessel protection. However, aligning system behavior with user preferences is challenging due to the difficulty of encoding expert intuition into reward functions. To address the issue, we propose a Reinforcement Learning with Human Feedback (RLHF) approach for MARL that resolves credit-assignment challenges through an Agent-Level Feedback system categorizing feedback into intra-agent, inter-agent, and intra-team types. To overcome the challenges of direct human feedback, we employ a Large Language Model (LLM) evaluator to validate our approach using feedback scenarios such as region constraints, collision avoidance, and task allocation. Our method effectively refines USV swarm policies, addressing key challenges in multi-agent systems while maintaining fairness and performance consistency.

Parallelized Planning-Acting for Efficient LLM-based Multi-Agent Systems

Authors:Yaoru Li, Shunyu Liu, Tongya Zheng, Mingli Song
Date:2025-03-05 13:53:10

Recent advancements in Large Language Model(LLM)-based Multi-Agent Systems(MAS) have demonstrated remarkable potential for tackling complex decision-making tasks. However, existing frameworks inevitably rely on serialized execution paradigms, where agents must complete sequential LLM planning before taking action. This fundamental constraint severely limits real-time responsiveness and adaptation, which is crucial in dynamic environments with ever-changing scenarios. In this paper, we propose a novel parallelized planning-acting framework for LLM-based MAS, featuring a dual-thread architecture with interruptible execution to enable concurrent planning and acting. Specifically, our framework comprises two core threads:(1) a planning thread driven by a centralized memory system, maintaining synchronization of environmental states and agent communication to support dynamic decision-making; and (2) an acting thread equipped with a comprehensive skill library, enabling automated task execution through recursive decomposition. Extensive experiments on challenging Minecraft demonstrate the effectiveness of the proposed framework.

Collaborative Expert LLMs Guided Multi-Objective Molecular Optimization

Authors:Jiajun Yu, Yizhen Zheng, Huan Yee Koh, Shirui Pan, Tianyue Wang, Haishuai Wang
Date:2025-03-05 13:47:55

Molecular optimization is a crucial yet complex and time-intensive process that often acts as a bottleneck for drug development. Traditional methods rely heavily on trial and error, making multi-objective optimization both time-consuming and resource-intensive. Current AI-based methods have shown limited success in handling multi-objective optimization tasks, hampering their practical utilization. To address this challenge, we present MultiMol, a collaborative large language model (LLM) system designed to guide multi-objective molecular optimization. MultiMol comprises two agents, including a data-driven worker agent and a literature-guided research agent. The data-driven worker agent is a large language model being fine-tuned to learn how to generate optimized molecules considering multiple objectives, while the literature-guided research agent is responsible for searching task-related literature to find useful prior knowledge that facilitates identifying the most promising optimized candidates. In evaluations across six multi-objective optimization tasks, MultiMol significantly outperforms existing methods, achieving a 82.30% success rate, in sharp contrast to the 27.50% success rate of current strongest methods. To further validate its practical impact, we tested MultiMol on two real-world challenges. First, we enhanced the selectivity of Xanthine Amine Congener (XAC), a promiscuous ligand that binds both A1R and A2AR, successfully biasing it towards A1R. Second, we improved the bioavailability of Saquinavir, an HIV-1 protease inhibitor with known bioavailability limitations. Overall, these results indicate that MultiMol represents a highly promising approach for multi-objective molecular optimization, holding great potential to accelerate the drug development process and contribute to the advancement of pharmaceutical research.

Open-Source Large Language Models as Multilingual Crowdworkers: Synthesizing Open-Domain Dialogues in Several Languages With No Examples in Targets and No Machine Translation

Authors:Ahmed Njifenjou, Virgile Sucal, Bassam Jabaian, Fabrice Lefèvre
Date:2025-03-05 12:52:14

The prevailing paradigm in the domain of Open-Domain Dialogue agents predominantly focuses on the English language, encompassing both models and datasets. Furthermore, the financial and temporal investments required for crowdsourcing such datasets for finetuning are substantial, particularly when multiple languages are involved. Fortunately, advancements in Large Language Models (LLMs) have unveiled a plethora of possibilities across diverse tasks. Specifically, instruction-tuning has enabled LLMs to execute tasks based on natural language instructions, occasionally surpassing the performance of human crowdworkers. Additionally, these models possess the capability to function in various languages within a single thread. Consequently, to generate new samples in different languages, we propose leveraging these capabilities to replicate the data collection process. We introduce a pipeline for generating Open-Domain Dialogue data in multiple Target Languages using LLMs, with demonstrations provided in a unique Source Language. By eschewing explicit Machine Translation in this approach, we enhance the adherence to language-specific nuances. We apply this methodology to the PersonaChat dataset. To enhance the openness of generated dialogues and mimic real life scenarii, we added the notion of speech events corresponding to the type of conversation the speakers are involved in and also that of common ground which represents the premises of a conversation.

Unified Mind Model: Reimagining Autonomous Agents in the LLM Era

Authors:Pengbo Hu, Xiang Ying
Date:2025-03-05 12:49:44

Large language models (LLMs) have recently demonstrated remarkable capabilities across domains, tasks, and languages (e.g., ChatGPT and GPT-4), reviving the research of general autonomous agents with human-like cognitive abilities. Such human-level agents require semantic comprehension and instruction-following capabilities, which exactly fall into the strengths of LLMs. Although there have been several initial attempts to build human-level agents based on LLMs, the theoretical foundation remains a challenging open problem. In this paper, we propose a novel theoretical cognitive architecture, the Unified Mind Model (UMM), which offers guidance to facilitate the rapid creation of autonomous agents with human-level cognitive abilities. Specifically, our UMM starts with the global workspace theory and further leverage LLMs to enable the agent with various cognitive abilities, such as multi-modal perception, planning, reasoning, tool use, learning, memory, reflection and motivation. Building upon UMM, we then develop an agent-building engine, MindOS, which allows users to quickly create domain-/task-specific autonomous agents without any programming effort.

Taxation Perspectives from Large Language Models: A Case Study on Additional Tax Penalties

Authors:Eunkyung Choi, Young Jin Suh, Hun Park, Wonseok Hwang
Date:2025-03-05 12:24:20

How capable are large language models (LLMs) in the domain of taxation? Although numerous studies have explored the legal domain in general, research dedicated to taxation remain scarce. Moreover, the datasets used in these studies are either simplified, failing to reflect the real-world complexities, or unavailable as open source. To address this gap, we introduce PLAT, a new benchmark designed to assess the ability of LLMs to predict the legitimacy of additional tax penalties. PLAT is constructed to evaluate LLMs' understanding of tax law, particularly in cases where resolving the issue requires more than just applying related statutes. Our experiments with six LLMs reveal that their baseline capabilities are limited, especially when dealing with conflicting issues that demand a comprehensive understanding. However, we found that enabling retrieval, self-reasoning, and discussion among multiple agents with specific role assignments, this limitation can be mitigated.

SEOE: A Scalable and Reliable Semantic Evaluation Framework for Open Domain Event Detection

Authors:Yi-Fan Lu, Xian-Ling Mao, Tian Lan, Tong Zhang, Yu-Shi Zhu, Heyan Huang
Date:2025-03-05 09:37:05

Automatic evaluation for Open Domain Event Detection (ODED) is a highly challenging task, because ODED is characterized by a vast diversity of un-constrained output labels from various domains. Nearly all existing evaluation methods for ODED usually first construct evaluation benchmarks with limited labels and domain coverage, and then evaluate ODED methods using metrics based on token-level label matching rules. However, this kind of evaluation framework faces two issues: (1) The limited evaluation benchmarks lack representatives of the real world, making it difficult to accurately reflect the performance of various ODED methods in real-world scenarios; (2) Evaluation metrics based on token-level matching rules fail to capture semantic similarity between predictions and golden labels. To address these two problems above, we propose a scalable and reliable Semantic-level Evaluation framework for Open domain Event detection (SEOE) by constructing a more representative evaluation benchmark and introducing a semantic evaluation metric. Specifically, our proposed framework first constructs a scalable evaluation benchmark that currently includes 564 event types covering 7 major domains, with a cost-effective supplementary annotation strategy to ensure the benchmark's representativeness. The strategy also allows for the supplement of new event types and domains in the future. Then, the proposed SEOE leverages large language models (LLMs) as automatic evaluation agents to compute a semantic F1-score, incorporating fine-grained definitions of semantically similar labels to enhance the reliability of the evaluation. Extensive experiments validate the representatives of the benchmark and the reliability of the semantic evaluation metric. Existing ODED methods are thoroughly evaluated, and the error patterns of predictions are analyzed, revealing several insightful findings.

Exploring the Potential of Large Language Models as Predictors in Dynamic Text-Attributed Graphs

Authors:Runlin Lei, Jiarui Ji, Haipeng Ding, Lu Yi, Zhewei Wei, Yongchao Liu, Chuntao Hong
Date:2025-03-05 08:28:11

With the rise of large language models (LLMs), there has been growing interest in Graph Foundation Models (GFMs) for graph-based tasks. By leveraging LLMs as predictors, GFMs have demonstrated impressive generalizability across various tasks and datasets. However, existing research on LLMs as predictors has predominantly focused on static graphs, leaving their potential in dynamic graph prediction unexplored. In this work, we pioneer using LLMs for predictive tasks on dynamic graphs. We identify two key challenges: the constraints imposed by context length when processing large-scale historical data and the significant variability in domain characteristics, both of which complicate the development of a unified predictor. To address these challenges, we propose the GraphAgent-Dynamic (GAD) Framework, a multi-agent system that leverages collaborative LLMs. In contrast to using a single LLM as the predictor, GAD incorporates global and local summary agents to generate domain-specific knowledge, enhancing its transferability across domains. Additionally, knowledge reflection agents enable adaptive updates to GAD's knowledge, maintaining a unified and self-consistent architecture. In experiments, GAD demonstrates performance comparable to or even exceeds that of full-supervised graph neural networks without dataset-specific training. Finally, to enhance the task-specific performance of LLM-based predictors, we discuss potential improvements, such as dataset-specific fine-tuning to LLMs. By developing tailored strategies for different tasks, we provide new insights for the future design of LLM-based predictors.

MA-LoT: Multi-Agent Lean-based Long Chain-of-Thought Reasoning enhances Formal Theorem Proving

Authors:Ruida Wang, Rui Pan, Yuxin Li, Jipeng Zhang, Yizhen Jia, Shizhe Diao, Renjie Pi, Junjie Hu, Tong Zhang
Date:2025-03-05 05:50:31

Solving mathematical problems using computer-verifiable languages like Lean has significantly impacted mathematical and computer science communities. State-of-the-art methods utilize single Large Language Models (LLMs) as agents or provers to either generate complete proof or perform tree searches. However, single-agent methods inherently lack a structured way to combine high-level reasoning in Natural Language (NL) with Formal Language (FL) verification feedback. To solve these issues, we propose MA-LoT: Multi-Agent Lean-based Long Chain-of-Thought framework, (to the best of our knowledge), the first multi-agent framework for Lean4 theorem proving that balance high-level NL reasoning and FL verification in Long CoT. Using this structured interaction, our approach enables deeper insights and long-term coherence in proof generation, with which past methods struggle. We do this by leveraging emergent formal reasoning ability in Long CoT using our novel LoT-Transfer Learning training-inference pipeline. Extensive experiments show that our framework achieves 54.51% accuracy rate on the Lean4 version of MiniF2F-Test dataset, largely outperforming GPT-4 (22.95%), single-agent tree search (InternLM-Step-Prover, 50.70%), and whole-proof generation (DeepSeek-Prover-v1.5, 48.36%) baselines. Furthermore, our findings highlight the potential of combining Long CoT with formal verification for a more insightful generation in a broader perspective.

Dango: A Mixed-Initiative Data Wrangling System using Large Language Model

Authors:Wei-Hao Chen, Weixi Tong, Amanda Case, Tianyi Zhang
Date:2025-03-05 03:54:51

Data wrangling is a time-consuming and challenging task in a data science pipeline. While many tools have been proposed to automate or facilitate data wrangling, they often misinterpret user intent, especially in complex tasks. We propose Dango, a mixed-initiative multi-agent system for data wrangling. Compared to existing tools, Dango enhances user communication of intent by allowing users to demonstrate on multiple tables and use natural language prompts in a conversation interface, enabling users to clarify their intent by answering LLM-posed multiple-choice clarification questions, and providing multiple forms of feedback such as step-by-step natural language explanations and data provenance to help users evaluate the data wrangling scripts. We conducted a within-subjects user study with 38 participants and demonstrated that Dango's features can significantly improve intent clarification, accuracy, and efficiency in data wrangling. Furthermore, we demonstrated the generalizability of Dango by applying it to a broader set of data wrangling tasks.

Teaching AI to Handle Exceptions: Supervised Fine-Tuning with Human-Aligned Judgment

Authors:Matthew DosSantos DiSorbo, Harang Ju, Sinan Aral
Date:2025-03-04 20:00:37

Large language models (LLMs), initially developed for generative AI, are now evolving into agentic AI systems, which make decisions in complex, real-world contexts. Unfortunately, while their generative capabilities are well-documented, their decision-making processes remain poorly understood. This is particularly evident when models are handling exceptions, a critical and challenging aspect of decision-making made relevant by the inherent incompleteness of contracts. Here we demonstrate that LLMs, even ones that excel at reasoning, deviate significantly from human judgments because they adhere strictly to policies, even when such adherence is impractical, suboptimal, or even counterproductive. We then evaluate three approaches to tuning AI agents to handle exceptions: ethical framework prompting, chain-of-thought reasoning, and supervised fine-tuning. We find that while ethical framework prompting fails and chain-of-thought prompting provides only slight improvements, supervised fine-tuning, specifically with human explanations, yields markedly better results. Surprisingly, in our experiments, supervised fine-tuning even enabled models to generalize human-like decision-making to novel scenarios, demonstrating transfer learning of human-aligned decision-making across contexts. Furthermore, fine-tuning with explanations, not just labels, was critical for alignment, suggesting that aligning LLMs with human judgment requires explicit training on how decisions are made, not just which decisions are made. These findings highlight the need to address LLMs' shortcomings in handling exceptions in order to guide the development of agentic AI toward models that can effectively align with human judgment and simultaneously adapt to novel contexts.

From Metaphor to Mechanism: How LLMs Decode Traditional Chinese Medicine Symbolic Language for Modern Clinical Relevance

Authors:Jiacheng Tang, Nankai Wu, Fan Gao, Chengxiao Dai, Mengyao Zhao, Xinjie Zhao
Date:2025-03-04 16:22:49

Metaphorical expressions are abundant in Traditional Chinese Medicine (TCM), conveying complex disease mechanisms and holistic health concepts through culturally rich and often abstract terminology. Bridging these metaphors to anatomically driven Western medical (WM) concepts poses significant challenges for both automated language processing and real-world clinical practice. To address this gap, we propose a novel multi-agent and chain-of-thought (CoT) framework designed to interpret TCM metaphors accurately and map them to WM pathophysiology. Specifically, our approach combines domain-specialized agents (TCM Expert, WM Expert) with a Coordinator Agent, leveraging stepwise chain-of-thought prompts to ensure transparent reasoning and conflict resolution. We detail a methodology for building a metaphor-rich TCM dataset, discuss strategies for effectively integrating multi-agent collaboration and CoT reasoning, and articulate the theoretical underpinnings that guide metaphor interpretation across distinct medical paradigms. We present a comprehensive system design and highlight both the potential benefits and limitations of our approach, while leaving placeholders for future experimental validation. Our work aims to support clinical decision-making, cross-system educational initiatives, and integrated healthcare research, ultimately offering a robust scaffold for reconciling TCM's symbolic language with the mechanistic focus of Western medicine.