Tool calling has emerged as a critical capability for AI agents to interact with the real world and solve complex tasks. While the Model Context Protocol (MCP) provides a powerful standardized framework for tool integration, there is a significant gap in benchmarking how well AI agents can effectively solve multi-step tasks using diverse MCP tools in realistic, dynamic scenarios. In this work, we present LiveMCP-101, a benchmark of 101 carefully curated real-world queries, refined through iterative LLM rewriting and manual review, that require coordinated use of multiple MCP tools including web search, file operations, mathematical reasoning, and data analysis. Moreover, we introduce a novel evaluation approach that leverages ground-truth execution plans rather than raw API outputs, better reflecting the evolving nature of real-world environments. Experiments show that even frontier LLMs achieve a success rate below 60\%, highlighting major challenges in tool orchestration. Detailed ablations and error analysis further reveal distinct failure modes and inefficiencies in token usage, pointing to concrete directions for advancing current models. LiveMCP-101 sets a rigorous standard for evaluating real-world agent capabilities, advancing toward autonomous AI systems that reliably execute complex tasks through tool use.
Accurate diagnosis with medical large language models is hindered by knowledge gaps and hallucinations. Retrieval and tool-augmented methods help, but their impact is limited by weak use of external knowledge and poor feedback-reasoning traceability. To address these challenges, We introduce Deep-DxSearch, an agentic RAG system trained end-to-end with reinforcement learning (RL) that enables steer tracebale retrieval-augmented reasoning for medical diagnosis. In Deep-DxSearch, we first construct a large-scale medical retrieval corpus comprising patient records and reliable medical knowledge sources to support retrieval-aware reasoning across diagnostic scenarios. More crutially, we frame the LLM as the core agent and the retrieval corpus as its environment, using tailored rewards on format, retrieval, reasoning structure, and diagnostic accuracy, thereby evolving the agentic RAG policy from large-scale data through RL. Experiments demonstrate that our end-to-end agentic RL training framework consistently outperforms prompt-engineering and training-free RAG approaches across multiple data centers. After training, Deep-DxSearch achieves substantial gains in diagnostic accuracy, surpassing strong diagnostic baselines such as GPT-4o, DeepSeek-R1, and other medical-specific frameworks for both common and rare disease diagnosis under in-distribution and out-of-distribution settings. Moreover, ablation studies on reward design and retrieval corpus components confirm their critical roles, underscoring the uniqueness and effectiveness of our approach compared with traditional implementations. Finally, case studies and interpretability analyses highlight improvements in Deep-DxSearch's diagnostic policy, providing deeper insight into its performance gains and supporting clinicians in delivering more reliable and precise preliminary diagnoses. See https://github.com/MAGIC-AI4Med/Deep-DxSearch.
We present NiceWebRL, a research tool that enables researchers to use machine reinforcement learning (RL) environments for online human subject experiments. NiceWebRL is a Python library that allows any Jax-based environment to be transformed into an online interface, supporting both single-agent and multi-agent environments. As such, NiceWebRL enables AI researchers to compare their algorithms to human performance, cognitive scientists to test ML algorithms as theories for human cognition, and multi-agent researchers to develop algorithms for human-AI collaboration. We showcase NiceWebRL with 3 case studies that demonstrate its potential to help develop Human-like AI, Human-compatible AI, and Human-assistive AI. In the first case study (Human-like AI), NiceWebRL enables the development of a novel RL model of cognition. Here, NiceWebRL facilitates testing this model against human participants in both a grid world and Craftax, a 2D Minecraft domain. In our second case study (Human-compatible AI), NiceWebRL enables the development of a novel multi-agent RL algorithm that can generalize to human partners in the Overcooked domain. Finally, in our third case study (Human-assistive AI), we show how NiceWebRL can allow researchers to study how an LLM can assist humans on complex tasks in XLand-Minigrid, an environment with millions of hierarchical tasks. The library is available at https://github.com/KempnerInstitute/nicewebrl.
This paper introduces Agentics, a modular framework for building agent-based systems capable of structured reasoning and compositional generalization over complex data. Designed with research and practical applications in mind, Agentics offers a novel perspective on working with data and AI workflows. In this framework, agents are abstracted from the logical flow and they are used internally to the data type to enable logical transduction among data. Agentics encourages AI developers to focus on modeling data rather than crafting prompts, enabling a declarative language in which data types are provided by LLMs and composed through logical transduction, which is executed by LLMs when types are connected. We provide empirical evidence demonstrating the applicability of this framework across domain-specific multiple-choice question answering, semantic parsing for text-to-SQL, and automated prompt optimization tasks, achieving state-of-the-art accuracy or improved scalability without sacrificing performance. The open-source implementation is available at \texttt{https://github.com/IBM/agentics}.
Traditional standardized network interfaces face significant limitations, including vendor-specific incompatibilities, rigid design assumptions, and lack of adaptability for new functionalities. We propose a multi-agent framework leveraging large language models (LLMs) to generate control interfaces on demand between network functions (NFs). This includes a matching agent, which aligns required control functionalities with NF capabilities, and a code-generation agent, which generates the necessary API server for interface realization. We validate our approach using simulated multi-vendor gNB and WLAN AP environments. The performance evaluations highlight the trade-offs between cost and latency across LLMs for interface generation tasks. Our work sets the foundation for AI-native dynamic control interface generation, paving the way for enhanced interoperability and adaptability in future mobile networks.
The rapid proliferation of large language models (LLMs) has intensified the requirement for reliable safety evaluation to uncover model vulnerabilities. To this end, numerous LLM safety evaluation benchmarks are proposed. However, existing benchmarks generally rely on labor-intensive manual curation, which causes excessive time and resource consumption. They also exhibit significant redundancy and limited difficulty. To alleviate these problems, we introduce SafetyFlow, the first agent-flow system designed to automate the construction of LLM safety benchmarks. SafetyFlow can automatically build a comprehensive safety benchmark in only four days without any human intervention by orchestrating seven specialized agents, significantly reducing time and resource cost. Equipped with versatile tools, the agents of SafetyFlow ensure process and cost controllability while integrating human expertise into the automatic pipeline. The final constructed dataset, SafetyFlowBench, contains 23,446 queries with low redundancy and strong discriminative power. Our contribution includes the first fully automated benchmarking pipeline and a comprehensive safety benchmark. We evaluate the safety of 49 advanced LLMs on our dataset and conduct extensive experiments to validate our efficacy and efficiency.
With the prospect of autonomous artificial intelligence (AI) agents, studying their tendency for cooperative behavior becomes an increasingly relevant topic. This study is inspired by the super-additive cooperation theory, where the combined effects of repeated interactions and inter-group rivalry have been argued to be the cause for cooperative tendencies found in humans. We devised a virtual tournament where language model agents, grouped into teams, face each other in a Prisoner's Dilemma game. By simulating both internal team dynamics and external competition, we discovered that this blend substantially boosts both overall and initial, one-shot cooperation levels (the tendency to cooperate in one-off interactions). This research provides a novel framework for large language models to strategize and act in complex social scenarios and offers evidence for how intergroup competition can, counter-intuitively, result in more cooperative behavior. These insights are crucial for designing future multi-agent AI systems that can effectively work together and better align with human values. Source code is available at https://github.com/pippot/Superadditive-cooperation-LLMs.
Large Language Models (LLMs) have shown promising potential in business applications, particularly in enterprise decision support and strategic planning, yet current approaches often struggle to reconcile intricate operational analyses with overarching strategic goals across diverse market environments, leading to fragmented workflows and reduced collaboration across organizational levels. This paper introduces BusiAgent, a novel multi-agent framework leveraging LLMs for advanced decision-making in complex corporate environments. BusiAgent integrates three core innovations: an extended Continuous Time Markov Decision Process (CTMDP) for dynamic agent modeling, a generalized entropy measure to optimize collaborative efficiency, and a multi-level Stackelberg game to handle hierarchical decision processes. Additionally, contextual Thompson sampling is employed for prompt optimization, supported by a comprehensive quality assurance system to mitigate errors. Extensive empirical evaluations across diverse business scenarios validate BusiAgent's efficacy, demonstrating its capacity to generate coherent, client-focused solutions that smoothly integrate granular insights with high-level strategy, significantly outperforming established approaches in both solution quality and user satisfaction. By fusing cutting-edge AI technologies with deep business insights, BusiAgent marks a substantial step forward in AI-driven enterprise decision-making, empowering organizations to navigate complex business landscapes more effectively.
Large language model (LLM) agents are widely deployed in real-world applications, where they leverage tools to retrieve and manipulate external data for complex tasks. However, when interacting with untrusted data sources (e.g., fetching information from public websites), tool responses may contain injected instructions that covertly influence agent behaviors and lead to malicious outcomes, a threat referred to as Indirect Prompt Injection (IPI). Existing defenses typically rely on advanced prompting strategies or auxiliary detection models. While these methods have demonstrated some effectiveness, they fundamentally rely on assumptions about the model's inherent security, which lacks structural constraints on agent behaviors. As a result, agents still retain unrestricted access to tool invocations, leaving them vulnerable to stronger attack vectors that can bypass the security guardrails of the model. To prevent malicious tool invocations at the source, we propose a novel defensive task execution paradigm, called IPIGuard, which models the agents' task execution process as a traversal over a planned Tool Dependency Graph (TDG). By explicitly decoupling action planning from interaction with external data, IPIGuard significantly reduces unintended tool invocations triggered by injected instructions, thereby enhancing robustness against IPI attacks. Experiments on the AgentDojo benchmark show that IPIGuard achieves a superior balance between effectiveness and robustness, paving the way for the development of safer agentic systems in dynamic environments.
Recent advancements in Large Language Models (LLMs) have driven growing interest in LLM-based agents for complex planning tasks. To avoid costly agent training, many studies adopted memory mechanism that enhances LLM with offline experiences or online trajectory analysis. However, existing works focus on single-granularity memory derived from dynamic environmental interactions, which are inherently constrained by the quality of the collected experiences. This limitation, in turn, constrain the diversity of knowledge and the flexibility of planning. We propose Coarse-to-Fine Grounded Memory (\Ours{}), a novel framework that grounds coarse-to-fine memories with LLM, thereby fully leverage them for flexible adaptation to diverse scenarios. \Ours{} grounds environmental information into coarse-grained focus points to guide experience collection in training tasks, followed by grounding of actionable hybrid-grained tips from each experience. At inference, \Ours{} retrieves task-relevant experiences and tips to support planning. When facing environmental anomalies, the LLM grounds the current situation into fine-grained key information, enabling flexible self-QA reflection and plan correction.
We present Comp-X, the first intelligently interactive image compression paradigm empowered by the impressive reasoning capability of large language model (LLM) agent. Notably, commonly used image codecs usually suffer from limited coding modes and rely on manual mode selection by engineers, making them unfriendly for unprofessional users. To overcome this, we advance the evolution of image coding paradigm by introducing three key innovations: (i) multi-functional coding framework, which unifies different coding modes of various objective/requirements, including human-machine perception, variable coding, and spatial bit allocation, into one framework. (ii) interactive coding agent, where we propose an augmented in-context learning method with coding expert feedback to teach the LLM agent how to understand the coding request, mode selection, and the use of the coding tools. (iii) IIC-bench, the first dedicated benchmark comprising diverse user requests and the corresponding annotations from coding experts, which is systematically designed for intelligently interactive image compression evaluation. Extensive experimental results demonstrate that our proposed Comp-X can understand the coding requests efficiently and achieve impressive textual interaction capability. Meanwhile, it can maintain comparable compression performance even with a single coding framework, providing a promising avenue for artificial general intelligence (AGI) in image compression.
We study sketch-to-diagram generation: converting rough hand sketches into precise, compositional diagrams. Diffusion models excel at photorealism but struggle with the spatial precision, alignment, and symbolic structure required for flowcharts. We introduce See it. Say it. Sorted., a training-free agentic system that couples a Vision-Language Model (VLM) with Large Language Models (LLMs) to produce editable Scalable Vector Graphics (SVG) programs. The system runs an iterative loop in which a Critic VLM proposes a small set of qualitative, relational edits; multiple candidate LLMs synthesize SVG updates with diverse strategies (conservative->aggressive, alternative, focused); and a Judge VLM selects the best candidate, ensuring stable improvement. This design prioritizes qualitative reasoning over brittle numerical estimates, preserves global constraints (e.g., alignment, connectivity), and naturally supports human-in-the-loop corrections. On 10 sketches derived from flowcharts in published papers, our method more faithfully reconstructs layout and structure than two frontier closed-source image generation LLMs (GPT-5 and Gemini-2.5-Pro), accurately composing primitives (e.g., multi-headed arrows) without inserting unwanted text. Because outputs are programmatic SVGs, the approach is readily extensible to presentation tools (e.g., PowerPoint) via APIs and can be specialized with improved prompts and task-specific tools. The codebase is open-sourced at https://github.com/hantaoZhangrichard/see_it_say_it_sorted.git.
Despite significant advancements in Large Language Models (LLMs) and Large Vision-Language Models (LVLMs), current models still face substantial challenges in handling complex, multi-turn, and visually-grounded tasks that demand deep reasoning, sustained contextual understanding, entity tracking, and multi-step instruction following. Existing benchmarks often fall short in capturing the dynamism and intricacies of real-world multi-modal interactions, leading to issues such as context loss and visual hallucinations. To address these limitations, we introduce MMDR-Bench (Multi-Modal Dialogue Reasoning Benchmark), a novel dataset comprising 300 meticulously designed complex multi-turn dialogue scenarios, each averaging 5-7 turns and evaluated across six core dimensions including visual entity tracking and reasoning depth. Furthermore, we propose CoLVLM Agent (Contextual LVLM Agent), a holistic framework that enhances existing LVLMs with advanced reasoning and instruction following capabilities through an iterative "memory-perception-planning-execution" cycle, requiring no extensive re-training of the underlying models. Our extensive experiments on MMDR-Bench demonstrate that CoLVLM Agent consistently achieves superior performance, attaining an average human evaluation score of 4.03, notably surpassing state-of-the-art commercial models like GPT-4o (3.92) and Gemini 1.5 Pro (3.85). The framework exhibits significant advantages in reasoning depth, instruction adherence, and error suppression, and maintains robust performance over extended dialogue turns, validating the effectiveness of its modular design and iterative approach for complex multi-modal interactions.
Recent advances in large language models (LLMs) have enabled AI agents to autonomously generate scientific proposals, conduct experiments, author papers, and perform peer reviews. Yet this flood of AI-generated research content collides with a fragmented and largely closed publication ecosystem. Traditional journals and conferences rely on human peer review, making them difficult to scale and often reluctant to accept AI-generated research content; existing preprint servers (e.g. arXiv) lack rigorous quality-control mechanisms. Consequently, a significant amount of high-quality AI-generated research lacks appropriate venues for dissemination, hindering its potential to advance scientific progress. To address these challenges, we introduce aiXiv, a next-generation open-access platform for human and AI scientists. Its multi-agent architecture allows research proposals and papers to be submitted, reviewed, and iteratively refined by both human and AI scientists. It also provides API and MCP interfaces that enable seamless integration of heterogeneous human and AI scientists, creating a scalable and extensible ecosystem for autonomous scientific discovery. Through extensive experiments, we demonstrate that aiXiv is a reliable and robust platform that significantly enhances the quality of AI-generated research proposals and papers after iterative revising and reviewing on aiXiv. Our work lays the groundwork for a next-generation open-access ecosystem for AI scientists, accelerating the publication and dissemination of high-quality AI-generated research content. Code is available at https://github.com/aixiv-org. Website is available at https://forms.gle/DxQgCtXFsJ4paMtn8.
Embodied AI agents must infer and act in an interpretable way on diverse human goals and preferences that are not predefined. To formalize this setting, we introduce Open-Universe Assistance Games (OU-AGs), a framework where the agent must reason over an unbounded and evolving space of possible goals. In this context, we introduce GOOD (GOals from Open-ended Dialogue), a data-efficient, online method that extracts goals in the form of natural language during an interaction with a human, and infers a distribution over natural language goals. GOOD prompts an LLM to simulate users with different complex intents, using its responses to perform probabilistic inference over candidate goals. This approach enables rich goal representations and uncertainty estimation without requiring large offline datasets. We evaluate GOOD in a text-based grocery shopping domain and in a text-operated simulated household robotics environment (AI2Thor), using synthetic user profiles. Our method outperforms a baseline without explicit goal tracking, as confirmed by both LLM-based and human evaluations.
In this work, we highlight the transformative potential of Artificial Intelligence (AI), particularly Large Language Models (LLMs) and agentic AI, in the insurance sector. We consider and emphasize the unique opportunities, challenges, and potential pathways in insurance amid rapid performance improvements, increased open-source access, decreasing deployment costs, and the complexity of LLM or agentic AI frameworks. To bring it closer to home, we identify critical gaps in the African insurance market and highlight key local efforts, players, and partnership opportunities. Finally, we call upon actuaries, insurers, regulators, and tech leaders to a collaborative effort aimed at creating inclusive, sustainable, and equitable AI strategies and solutions: by and for Africans.
Adapting Large Language Models (LLMs) using parameter-efficient fine-tuning (PEFT) techniques such as LoRA has enabled powerful capabilities in LLM-based agents. However, these adaptations can unintentionally compromise safety alignment, leading to unsafe or unstable behaviors, particularly in agent planning tasks. Existing safety-aware adaptation methods often require access to both base and instruction-tuned model checkpoints, which are frequently unavailable in practice, limiting their applicability. We propose S3LoRA (Safe Spectral Sharpness-Guided Pruning LoRA), a lightweight, data-free, and model-independent framework that mitigates safety risks in LoRA-adapted models by inspecting only the fine-tuned weight updates. We first introduce Magnitude-Aware Spherically Normalized SVD (MAS-SVD), which robustly analyzes the structural properties of LoRA updates while preserving global magnitude information. We then design the Spectral Sharpness Index (SSI), a sharpness-aware metric to detect layers with highly concentrated and potentially unsafe updates. These layers are pruned post-hoc to reduce risk without sacrificing task performance. Extensive experiments and ablation studies across agent planning and language generation tasks show that S3LoRA consistently improves safety metrics while maintaining or improving utility metrics and significantly reducing inference cost. These results establish S3LoRA as a practical and scalable solution for safely deploying LLM-based agents in real-world, resource-constrained, and safety-critical environments.
Animating and simulating crowds using an agent-based approach is a well-established area where every agent in the crowd is individually controlled such that global human-like behaviour emerges. We observe that human navigation and movement in crowds are often influenced by complex social and environmental interactions, driven mainly by language and dialogue. However, most existing work does not consider these dimensions and leads to animations where agent-agent and agent-environment interactions are largely limited to steering and fixed higher-level goal extrapolation. We propose a novel method that exploits large language models (LLMs) to control agents' movement. Our method has two main components: a dialogue system and language-driven navigation. We periodically query agent-centric LLMs conditioned on character personalities, roles, desires, and relationships to control the generation of inter-agent dialogue when necessitated by the spatial and social relationships with neighbouring agents. We then use the conversation and each agent's personality, emotional state, vision, and physical state to control the navigation and steering of each agent. Our model thus enables agents to make motion decisions based on both their perceptual inputs and the ongoing dialogue. We validate our method in two complex scenarios that exemplify the interplay between social interactions, steering, and crowding. In these scenarios, we observe that grouping and ungrouping of agents automatically occur. Additionally, our experiments show that our method serves as an information-passing mechanism within the crowd. As a result, our framework produces more realistic crowd simulations, with emergent group behaviours arising naturally from any environmental setting.
We propose Collab-REC, a multi-agent framework designed to counteract popularity bias and enhance diversity in tourism recommendations. In our setting, three LLM-based agents -- Personalization, Popularity, and Sustainability generate city suggestions from complementary perspectives. A non-LLM moderator then merges and refines these proposals via multi-round negotiation, ensuring each agent's viewpoint is incorporated while penalizing spurious or repeated responses. Experiments on European city queries show that Collab-REC improves diversity and overall relevance compared to a single-agent baseline, surfacing lesser-visited locales that often remain overlooked. This balanced, context-aware approach addresses over-tourism and better aligns with constraints provided by the user, highlighting the promise of multi-stakeholder collaboration in LLM-driven recommender systems.
Recent developments in Large Language Model (LLM)-based agents have shown impressive capabilities spanning multiple domains, exemplified by deep research systems that demonstrate superior performance on complex information-seeking and synthesis tasks. While general-purpose deep research agents have shown impressive capabilities, they struggle significantly with medical domain challenges, as evidenced by leading proprietary systems achieving limited accuracy on complex medical benchmarks. The key limitations are: (1) the model lacks sufficient dense medical knowledge for clinical reasoning, and (2) the framework is constrained by the absence of specialized retrieval tools tailored for medical contexts.We present a medical deep research agent that addresses these challenges through two core innovations. First, we develop a novel data synthesis framework using medical knowledge graphs, extracting the longest chains from subgraphs around rare medical entities to generate complex multi-hop question-answer pairs. Second, we integrate a custom-built private medical retrieval engine alongside general-purpose tools, enabling accurate medical information synthesis. Our approach generates 2100+ diverse trajectories across 12 medical specialties, each averaging 4.2 tool interactions.Through a two-stage training paradigm combining supervised fine-tuning and online reinforcement learning with composite rewards, our MedResearcher-R1-32B model demonstrates exceptional performance, establishing new state-of-the-art results on medical benchmarks while maintaining competitive performance on general deep research tasks. Our work demonstrates that strategic domain-specific innovations in architecture, tool design, and training data construction can enable smaller open-source models to outperform much larger proprietary systems in specialized domains.
Open-ended AI agents need to be able to learn efficiently goals of increasing complexity, abstraction and heterogeneity over their lifetime. Beyond sampling efficiently their own goals, autotelic agents specifically need to be able to keep the growing complexity of goals under control, limiting the associated growth in sample and computational complexity. To adress this challenge, recent approaches have leveraged hierarchical reinforcement learning (HRL) and language, capitalizing on its compositional and combinatorial generalization capabilities to acquire temporally extended reusable behaviours. Existing approaches use expert defined spaces of subgoals over which they instantiate a hierarchy, and often assume pre-trained associated low-level policies. Such designs are inadequate in open-ended scenarios, where goal spaces naturally diversify across a broad spectrum of difficulties. We introduce HERAKLES, a framework that enables a two-level hierarchical autotelic agent to continuously compile mastered goals into the low-level policy, executed by a small, fast neural network, dynamically expanding the set of subgoals available to the high-level policy. We train a Large Language Model (LLM) to serve as the high-level controller, exploiting its strengths in goal decomposition and generalization to operate effectively over this evolving subgoal space. We evaluate HERAKLES in the open-ended Crafter environment and show that it scales effectively with goal complexity, improves sample efficiency through skill compilation, and enables the agent to adapt robustly to novel challenges over time.
The Model Context Protocol has emerged as a transformative standard for connecting large language models to external data sources and tools, rapidly gaining adoption across major AI providers and development platforms. However, existing benchmarks are overly simplistic and fail to capture real application challenges such as long-horizon reasoning and large, unfamiliar tool spaces. To address this critical gap, we introduce MCP-Universe, the first comprehensive benchmark specifically designed to evaluate LLMs in realistic and hard tasks through interaction with real-world MCP servers. Our benchmark encompasses 6 core domains spanning 11 different MCP servers: Location Navigation, Repository Management, Financial Analysis, 3D Design, Browser Automation, and Web Searching. To ensure rigorous evaluation, we implement execution-based evaluators, including format evaluators for agent format compliance, static evaluators for time-invariant content matching, and dynamic evaluators that automatically retrieve real-time ground truth for temporally sensitive tasks. Through extensive evaluation of leading LLMs, we find that even SOTA models such as GPT-5 (43.72%), Grok-4 (33.33%) and Claude-4.0-Sonnet (29.44%) exhibit significant performance limitations. In addition, our benchmark poses a significant long-context challenge for LLM agents, as the number of input tokens increases rapidly with the number of interaction steps. Moreover, it introduces an unknown-tools challenge, as LLM agents often lack familiarity with the precise usage of the MCP servers. Notably, enterprise-level agents like Cursor cannot achieve better performance than standard ReAct frameworks. Beyond evaluation, we open-source our extensible evaluation framework with UI support, enabling researchers and practitioners to seamlessly integrate new agents and MCP servers while fostering innovation in the rapidly evolving MCP ecosystem.
In recent years, the increasing frequency of extreme urban rainfall events has posed significant challenges to emergency scheduling systems. Urban flooding often leads to severe traffic congestion and service disruptions, threatening public safety and mobility. However, effective decision making remains hindered by three key challenges: (1) managing trade-offs among competing goals (e.g., traffic flow, task completion, and risk mitigation) requires dynamic, context-aware strategies; (2) rapidly evolving environmental conditions render static rules inadequate; and (3) LLM-generated strategies frequently suffer from semantic instability and execution inconsistency. Existing methods fail to align perception, global optimization, and multi-agent coordination within a unified framework. To tackle these challenges, we introduce H-J, a hierarchical multi-agent framework that integrates knowledge-guided prompting, entropy-constrained generation, and feedback-driven optimization. The framework establishes a closed-loop pipeline spanning from multi-source perception to strategic execution and continuous refinement. We evaluate H-J on real-world urban topology and rainfall data under three representative conditions: extreme rainfall, intermittent bursts, and daily light rain. Experiments show that H-J outperforms rule-based and reinforcement-learning baselines in traffic smoothness, task success rate, and system robustness. These findings highlight the promise of uncertainty-aware, knowledge-constrained LLM-based approaches for enhancing resilience in urban flood response.
The ability to coordinate actions across multiple agents is critical for solving complex, real-world problems. Large Language Models (LLMs) have shown strong capabilities in communication, planning, and reasoning, raising the question of whether they can also support effective collaboration in multi-agent settings. In this work, we investigate the use of LLM agents to solve a structured victim rescue task that requires division of labor, prioritization, and cooperative planning. Agents operate in a fully known graph-based environment and must allocate resources to victims with varying needs and urgency levels. We systematically evaluate their performance using a suite of coordination-sensitive metrics, including task success rate, redundant actions, room conflicts, and urgency-weighted efficiency. This study offers new insights into the strengths and failure modes of LLMs in physically grounded multi-agent collaboration tasks, contributing to future benchmarks and architectural improvements.
Recent advances in large language models (LLMs) and reasoning frameworks have opened new possibilities for improving the perspective -taking capabilities of autonomous agents. However, tasks that involve active perception, collaborative reasoning, and perspective taking (understanding what another agent can see or knows) pose persistent challenges for current LLM-based systems. This study investigates the potential of structured examples derived from transformed solution graphs generated by the Fast Downward planner to improve the performance of LLM-based agents within a ReAct framework. We propose a structured solution-processing pipeline that generates three distinct categories of examples: optimal goal paths (G-type), informative node paths (E-type), and step-by-step optimal decision sequences contrasting alternative actions (L-type). These solutions are further converted into ``thought-action'' examples by prompting an LLM to explicitly articulate the reasoning behind each decision. While L-type examples slightly reduce clarification requests and overall action steps, they do not yield consistent improvements. Agents are successful in tasks requiring basic attentional filtering but struggle in scenarios that required mentalising about occluded spaces or weighing the costs of epistemic actions. These findings suggest that structured examples alone are insufficient for robust perspective-taking, underscoring the need for explicit belief tracking, cost modelling, and richer environments to enable socially grounded collaboration in LLM-based agents.
Optimization Modeling (OM) is essential for solving complex decision-making problems. However, the process remains time-consuming and error-prone, heavily relying on domain experts. While Large Language Models (LLMs) show promise in addressing these challenges through their natural language understanding and reasoning capabilities, current approaches face three critical limitations: high benchmark labeling error rates reaching up to 42\%, narrow evaluation scope that only considers optimal values, and computational inefficiency due to heavy reliance on multi-agent systems or model fine-tuning. In this work, we first enhance existing datasets through systematic error correction and more comprehensive annotation. Additionally, we introduce LogiOR, a new optimization modeling benchmark from the logistics domain, containing more complex problems with standardized annotations. Furthermore, we present ORThought, a novel framework that leverages expert-level optimization modeling principles through chain-of-thought reasoning to automate the OM process. Through extensive empirical evaluation, we demonstrate that ORThought outperforms existing approaches, including multi-agent frameworks, with particularly significant advantages on complex optimization problems. Finally, we provide a systematic analysis of our method, identifying critical success factors and failure modes, providing valuable insights for future research on LLM-based optimization modeling.
Accurate lung cancer risk prediction remains challenging due to substantial variability across patient populations and clinical settings -- no single model performs best for all cohorts. To address this, we propose a personalized lung cancer risk prediction agent that dynamically selects the most appropriate model for each patient by combining cohort-specific knowledge with modern retrieval and reasoning techniques. Given a patient's CT scan and structured metadata -- including demographic, clinical, and nodule-level features -- the agent first performs cohort retrieval using FAISS-based similarity search across nine diverse real-world cohorts to identify the most relevant patient population from a multi-institutional database. Second, a Large Language Model (LLM) is prompted with the retrieved cohort and its associated performance metrics to recommend the optimal prediction algorithm from a pool of eight representative models, including classical linear risk models (e.g., Mayo, Brock), temporally-aware models (e.g., TDVIT, DLSTM), and multi-modal computer vision-based approaches (e.g., Liao, Sybil, DLS, DLI). This two-stage agent pipeline -- retrieval via FAISS and reasoning via LLM -- enables dynamic, cohort-aware risk prediction personalized to each patient's profile. Building on this architecture, the agent supports flexible and cohort-driven model selection across diverse clinical populations, offering a practical path toward individualized risk assessment in real-world lung cancer screening.
Recent advances in large language models (LLMs) have enabled new possibilities in simulating complex physiological systems. We introduce Organ-Agents, a multi-agent framework that simulates human physiology via LLM-driven agents. Each Simulator models a specific system (e.g., cardiovascular, renal, immune). Training consists of supervised fine-tuning on system-specific time-series data, followed by reinforcement-guided coordination using dynamic reference selection and error correction. We curated data from 7,134 sepsis patients and 7,895 controls, generating high-resolution trajectories across 9 systems and 125 variables. Organ-Agents achieved high simulation accuracy on 4,509 held-out patients, with per-system MSEs <0.16 and robustness across SOFA-based severity strata. External validation on 22,689 ICU patients from two hospitals showed moderate degradation under distribution shifts with stable simulation. Organ-Agents faithfully reproduces critical multi-system events (e.g., hypotension, hyperlactatemia, hypoxemia) with coherent timing and phase progression. Evaluation by 15 critical care physicians confirmed realism and physiological plausibility (mean Likert ratings 3.9 and 3.7). Organ-Agents also enables counterfactual simulations under alternative sepsis treatment strategies, generating trajectories and APACHE II scores aligned with matched real-world patients. In downstream early warning tasks, classifiers trained on synthetic data showed minimal AUROC drops (<0.04), indicating preserved decision-relevant patterns. These results position Organ-Agents as a credible, interpretable, and generalizable digital twin for precision diagnosis, treatment simulation, and hypothesis testing in critical care.
Traditional protocol fuzzing techniques, such as those employed by AFL-based systems, often lack effectiveness due to a limited semantic understanding of complex protocol grammars and rigid seed mutation strategies. Recent works, such as ChatAFL, have integrated Large Language Models (LLMs) to guide protocol fuzzing and address these limitations, pushing protocol fuzzers to wider exploration of the protocol state space. But ChatAFL still faces issues like unreliable output, LLM hallucinations, and assumptions of LLM knowledge about protocol specifications. This paper introduces MultiFuzz, a novel dense retrieval-based multi-agent system designed to overcome these limitations by integrating semantic-aware context retrieval, specialized agents, and structured tool-assisted reasoning. MultiFuzz utilizes agentic chunks of protocol documentation (RFC Documents) to build embeddings in a vector database for a retrieval-augmented generation (RAG) pipeline, enabling agents to generate more reliable and structured outputs, enhancing the fuzzer in mutating protocol messages with enhanced state coverage and adherence to syntactic constraints. The framework decomposes the fuzzing process into modular groups of agents that collaborate through chain-of-thought reasoning to dynamically adapt fuzzing strategies based on the retrieved contextual knowledge. Experimental evaluations on the Real-Time Streaming Protocol (RTSP) demonstrate that MultiFuzz significantly improves branch coverage and explores deeper protocol states and transitions over state-of-the-art (SOTA) fuzzers such as NSFuzz, AFLNet, and ChatAFL. By combining dense retrieval, agentic coordination, and language model reasoning, MultiFuzz establishes a new paradigm in autonomous protocol fuzzing, offering a scalable and extensible foundation for future research in intelligent agentic-based fuzzing systems.
Emotions exert an immense influence over human behavior and cognition in both commonplace and high-stress tasks. Discussions of whether or how to integrate large language models (LLMs) into everyday life (e.g., acting as proxies for, or interacting with, human agents), should be informed by an understanding of how these tools evaluate emotionally loaded stimuli or situations. A model's alignment with human behavior in these cases can inform the effectiveness of LLMs for certain roles or interactions. To help build this understanding, we elicited ratings from multiple popular LLMs for datasets of words and images that were previously rated for their emotional content by humans. We found that when performing the same rating tasks, GPT-4o responded very similarly to human participants across modalities, stimuli and most rating scales (r = 0.9 or higher in many cases). However, arousal ratings were less well aligned between human and LLM raters, while happiness ratings were most highly aligned. Overall LLMs aligned better within a five-category (happiness, anger, sadness, fear, disgust) emotion framework than within a two-dimensional (arousal and valence) organization. Finally, LLM ratings were substantially more homogenous than human ratings. Together these results begin to describe how LLM agents interpret emotional stimuli and highlight similarities and differences among biological and artificial intelligence in key behavioral domains.