Urban transportation systems encounter diverse challenges across multiple tasks, such as traffic forecasting, electric vehicle (EV) charging demand prediction, and taxi dispatch. Existing approaches suffer from two key limitations: small-scale deep learning models are task-specific and data-hungry, limiting their generalizability across diverse scenarios, while large language models (LLMs), despite offering flexibility through natural language interfaces, struggle with structured spatiotemporal data and numerical reasoning in transportation domains. To address these limitations, we propose TransLLM, a unified foundation framework that integrates spatiotemporal modeling with large language models through learnable prompt composition. Our approach features a lightweight spatiotemporal encoder that captures complex dependencies via dilated temporal convolutions and dual-adjacency graph attention networks, seamlessly interfacing with LLMs through structured embeddings. A novel instance-level prompt routing mechanism, trained via reinforcement learning, dynamically personalizes prompts based on input characteristics, moving beyond fixed task-specific templates. The framework operates by encoding spatiotemporal patterns into contextual representations, dynamically composing personalized prompts to guide LLM reasoning, and projecting the resulting representations through specialized output layers to generate task-specific predictions. Experiments across seven datasets and three tasks demonstrate the exceptional effectiveness of TransLLM in both supervised and zero-shot settings. Compared to ten baseline models, it delivers competitive performance on both regression and planning problems, showing strong generalization and cross-task adaptability. Our code is available at https://github.com/BiYunying/TransLLM.
The ability to coordinate actions across multiple agents is critical for solving complex, real-world problems. Large Language Models (LLMs) have shown strong capabilities in communication, planning, and reasoning, raising the question of whether they can also support effective collaboration in multi-agent settings. In this work, we investigate the use of LLM agents to solve a structured victim rescue task that requires division of labor, prioritization, and cooperative planning. Agents operate in a fully known graph-based environment and must allocate resources to victims with varying needs and urgency levels. We systematically evaluate their performance using a suite of coordination-sensitive metrics, including task success rate, redundant actions, room conflicts, and urgency-weighted efficiency. This study offers new insights into the strengths and failure modes of LLMs in physically grounded multi-agent collaboration tasks, contributing to future benchmarks and architectural improvements.
Online coordination of multi-robot systems in open and unknown environments faces significant challenges, particularly when semantic features detected during operation dynamically trigger new tasks. Recent large language model (LLMs)-based approaches for scene reasoning and planning primarily focus on one-shot, end-to-end solutions in known environments, lacking both dynamic adaptation capabilities for online operation and explainability in the processes of planning. To address these issues, a novel framework (DEXTER-LLM) for dynamic task planning in unknown environments, integrates four modules: (i) a mission comprehension module that resolves partial ordering of tasks specified by natural languages or linear temporal logic formulas (LTL); (ii) an online subtask generator based on LLMs that improves the accuracy and explainability of task decomposition via multi-stage reasoning; (iii) an optimal subtask assigner and scheduler that allocates subtasks to robots via search-based optimization; and (iv) a dynamic adaptation and human-in-the-loop verification module that implements multi-rate, event-based updates for both subtasks and their assignments, to cope with new features and tasks detected online. The framework effectively combines LLMs' open-world reasoning capabilities with the optimality of model-based assignment methods, simultaneously addressing the critical issue of online adaptability and explainability. Experimental evaluations demonstrate exceptional performances, with 100% success rates across all scenarios, 160 tasks and 480 subtasks completed on average (3 times the baselines), 62% less queries to LLMs during adaptation, and superior plan quality (2 times higher) for compound tasks. Project page at https://tcxm.github.io/DEXTER-LLM/
Survey papers play a critical role in scientific communication by consolidating progress across a field. Recent advances in Large Language Models (LLMs) offer a promising solution by automating key steps in the survey-generation pipeline, such as retrieval, structuring, and summarization. However, existing LLM-based approaches often struggle with maintaining coherence across long, multi-section surveys and providing comprehensive citation coverage. To address these limitations, we introduce SurveyGen-I, an automatic survey generation framework that combines coarse-to-fine retrieval, adaptive planning, and memory-guided generation. SurveyGen-I first performs survey-level retrieval to construct the initial outline and writing plan, and then dynamically refines both during generation through a memory mechanism that stores previously written content and terminology, ensuring coherence across subsections. When the system detects insufficient context, it triggers fine-grained subsection-level retrieval. During generation, SurveyGen-I leverages this memory mechanism to maintain coherence across subsections. Experiments across four scientific domains demonstrate that SurveyGen-I consistently outperforms previous works in content quality, consistency, and citation coverage.
Beyond simple text generation, Large Language Models (LLMs) have evolved into agentic systems capable of planning and interacting with external tools to solve complex tasks. This evolution involves fine-tuning LLMs on agent-specific tasks to enhance their proficiency. However, safety concerns are frequently overlooked during this fine-tuning process. In this work, we show that aligned LLMs can become unintentionally misaligned, leading to a higher likelihood of executing harmful tasks and a reduced tendency to refuse them when fine-tuned to execute agentic tasks. To address these safety challenges, we propose Prefix INjection Guard (PING), a simple yet effective method that prepends automatically generated natural language prefixes to agent responses, guiding them to refuse harmful requests while preserving performance on benign tasks. Specifically, we introduce an iterative approach that alternates between (1) generating candidate prefixes and (2) selecting those that optimize both task performance and refusal behavior. Experimental results demonstrate that PING significantly enhances the safety of fine-tuned LLM agents without sacrificing their effectiveness. PING consistently outperforms existing prompting approaches across diverse benchmarks in both web navigation and code generation tasks. Our analysis of internal hidden states via linear probes reveals that prefix tokens are crucial for behavior modification, explaining the performance gains. WARNING: This paper contains contents that are unethical or offensive in nature.
LLMs have recently been used to generate Python programs representing generalized plans in PDDL planning, i.e., plans that generalize across the tasks of a given PDDL domain. Previous work proposed a framework consisting of three steps: the LLM first generates a summary and then a strategy for the domain, both in natural language, and then implements that strategy as a Python program, that gets debugged on example planning tasks. In that work, only one strategy is generated and passed directly to the program generation. If the strategy is incorrect, its implementation will therefore result in an incorrect generalized plan. Here, we introduce an approach that generates the strategy in the form of pseudocode and enables automatic debugging of the pseudocode, hence allowing us to identify and fix errors prior to the generation of the generalized plan itself. Additionally, we extend the Python debugging phase with a reflection step prompting the LLM to pinpoint the reason for the observed plan failure. Finally, we take inspiration from LLM code generation to produce several program variants and pick the best one. Running experiments on 17 benchmark domains, we show that these extensions substantially improve (and never deteriorate) the quality of the generalized plans. In 12 of the domains, our best Python programs solve all tasks that can be generated with the respective instance generator.
Recent multi-agent frameworks built upon large language models (LLMs) have demonstrated remarkable capabilities in complex task planning. However, in real-world enterprise environments, business workflows are typically composed through modularization and reuse of numerous subprocesses, resulting in intricate workflows characterized by lengthy and deeply nested execution paths. Such complexity poses significant challenges for LLM-driven orchestration, as extended reasoning chains and state-space explosions severely impact planning effectiveness and the proper sequencing of tool invocations. Therefore, developing an orchestration method with controllable structures capable of handling multi-layer nesting becomes a critical issue. To address this, we propose a novel structure-driven orchestration framework Self-Organizing Agent Network (SOAN). SOAN incrementally builds a formalized agent network by identifying and encapsulating structural units as independent agents, enhancing modularity and clarity in orchestration. Extensive evaluations were performed using multiple benchmarks as well as a real-world enterprise workflow dataset. Experimental results demonstrate that SOAN significantly outperforms state-of-the-art methods in terms of adaptability, fault tolerance, and execution efficiency.
Large language model (LLM) agents-especially smaller, open-source models-often produce causally invalid or incoherent actions in collaborative tasks due to their reliance on surface-level correlations rather than grounded causal reasoning. This limitation undermines their performance in terms of coordination and planning in dynamic environments. We address this challenge with CausalPlan, a two-phase framework that integrates explicit structural causal reasoning into the LLM planning process. At the core of CausalPlan is the Structural Causal Action (SCA) model, which learns a causal graph from agent trajectories to capture how prior actions and current environment states influence future decisions. This structure is then used to guide action selection by assigning causal scores to LLM-generated proposals, reweighting them accordingly, or falling back to causally grounded alternatives when needed. By embedding this causal knowledge directly into the decision loop, CausalPlan constrains planning to intervention-consistent behaviours without requiring fine-tuning of the LLM itself. We evaluate CausalPlan on the Overcooked-AI benchmark across five multi-agent coordination tasks and four LLMs of varying sizes: Gemma-7B, Llama-8B, Qwen-14B, and Llama-70B. Experimental results show that CausalPlan consistently reduces invalid actions and improves collaboration in both AI-AI and human-AI settings, outperforming strong reinforcement learning baselines. Our findings highlight the value of causality-driven planning for deploying efficient, interpretable, and generalisable multi-agent LLM systems.
Planning is one of the most critical tasks in autonomous systems, where even a small error can lead to major failures or million-dollar losses. Current state-of-the-art neural planning approaches struggle with complex domains, producing plans with missing preconditions, inconsistent goals, and hallucinations. While classical planners provide logical guarantees, they lack the flexibility and natural language understanding capabilities needed for modern autonomous systems. Existing neuro-symbolic approaches use one-shot translation from natural language to formal plans, missing the opportunity for neural and symbolic components to work and refine solutions together. To address this gap, we develop LOOP -- a novel neuro-symbolic planning framework that treats planning as an iterative conversation between neural and symbolic components rather than simple translation. LOOP integrates 13 coordinated neural features including graph neural networks for spatial relationships, multi-agent validation for consensus-based correctness, hierarchical decomposition for complex task management, and causal memory that learns from both successes and failures. Unlike existing approaches, LOOP generates PDDL specifications, refines them iteratively based on symbolic feedback, and builds a causal knowledge base from execution traces. LOOP was evaluated on six standard IPC benchmark domains, where it achieved 85.8% success rate compared to LLM+P (55.0%), LLM-as-Planner (19.2%), and Tree-of-Thoughts (3.3%). This work shows that the key to reliable planning is not in choosing between neural networks or symbolic reasoners but it lies in making them actually ``talk'' to each other during the entire process. LOOP provides a thorough blueprint for building autonomous systems that can finally be trusted with critical real-world applications.
Autonomous agent systems powered by Large Language Models (LLMs) have demonstrated promising capabilities in automating complex tasks. However, current evaluations largely rely on success rates without systematically analyzing the interactions, communication mechanisms, and failure causes within these systems. To bridge this gap, we present a benchmark of 34 representative programmable tasks designed to rigorously assess autonomous agents. Using this benchmark, we evaluate three popular open-source agent frameworks combined with two LLM backbones, observing a task completion rate of approximately 50%. Through in-depth failure analysis, we develop a three-tier taxonomy of failure causes aligned with task phases, highlighting planning errors, task execution issues, and incorrect response generation. Based on these insights, we propose actionable improvements to enhance agent planning and self-diagnosis capabilities. Our failure taxonomy, together with mitigation advice, provides an empirical foundation for developing more robust and effective autonomous agent systems in the future.
Multi-agent systems (MASs) have pushed the boundaries of large language model (LLM) agents in domains such as web research and software engineering. However, long-horizon, multi-constraint planning tasks involve conditioning on detailed information and satisfying complex interdependent constraints, which can pose a challenge for these systems. In this study, we construct an LLM-based MAS for a travel planning task which is representative of these challenges. We evaluate the impact of a notebook to facilitate information sharing, and evaluate an orchestrator agent to improve coordination in free form conversation between agents. We find that the notebook reduces errors due to hallucinated details by 18%, while an orchestrator directs the MAS to focus on and further reduce errors by up to 13.5% within focused sub-areas. Combining both mechanisms achieves a 25% final pass rate on the TravelPlanner benchmark, a 17.5% absolute improvement over the single-agent baseline's 7.5% pass rate. These results highlight the potential of structured information sharing and reflective orchestration as key components in MASs for long horizon planning with LLMs.
In this study, we disclose a worrying new vulnerability in Large Language Models (LLMs), which we term \textbf{involuntary jailbreak}. Unlike existing jailbreak attacks, this weakness is distinct in that it does not involve a specific attack objective, such as generating instructions for \textit{building a bomb}. Prior attack methods predominantly target localized components of the LLM guardrail. In contrast, involuntary jailbreaks may potentially compromise the entire guardrail structure, which our method reveals to be surprisingly fragile. We merely employ a single universal prompt to achieve this goal. In particular, we instruct LLMs to generate several questions that would typically be rejected, along with their corresponding in-depth responses (rather than a refusal). Remarkably, this simple prompt strategy consistently jailbreaks the majority of leading LLMs, including Claude Opus 4.1, Grok 4, Gemini 2.5 Pro, and GPT 4.1. We hope this problem can motivate researchers and practitioners to re-evaluate the robustness of LLM guardrails and contribute to stronger safety alignment in future.
Large language models (LLMs) have shown remarkable capabilities in isolated step-by-step reasoning tasks such as mathematics and programming, but their proficiency in long-horizon planning, where solutions require extended, structured sequences of interdependent actions, remains underexplored. Existing benchmarks typically assess LLMs through abstract or low-dimensional algorithmic tasks, failing to capture the complexity of realistic planning environments. We introduce HeroBench, a novel benchmark designed specifically to evaluate long-horizon planning and structured reasoning within complex RPG-inspired virtual worlds. HeroBench provides a rigorously constructed dataset of tasks covering a wide range of difficulties, a simulated environment to execute and validate agent plans, and detailed analytical tools for evaluating model performance. Tasks challenge models to formulate strategic plans, efficiently gather resources, master necessary skills, craft equipment, and defeat adversaries, reflecting practical scenarios' layered dependencies and constraints. Our extensive evaluation of 25 state-of-the-art LLMs, spanning both open-source and proprietary models, including the GPT-5 family, reveals substantial performance disparities rarely observed in conventional reasoning benchmarks. Detailed error analysis further uncovers specific weaknesses in current models' abilities to generate robust high-level plans and reliably execute structured actions. HeroBench thus not only significantly advances the evaluation of LLM reasoning but also provides a flexible, scalable foundation for future research into advanced, autonomous planning in virtual environments.
The rapid advancement of large language models (LLMs) has driven the development of agentic systems capable of autonomously performing complex tasks. Despite their impressive capabilities, LLMs remain constrained by their internal knowledge boundaries. To overcome these limitations, the paradigm of deep research has been proposed, wherein agents actively engage in planning, retrieval, and synthesis to generate comprehensive and faithful analytical reports grounded in web-based evidence. In this survey, we provide a systematic overview of the deep research pipeline, which comprises four core stages: planning, question developing, web exploration, and report generation. For each stage, we analyze the key technical challenges and categorize representative methods developed to address them. Furthermore, we summarize recent advances in optimization techniques and benchmarks tailored for deep research. Finally, we discuss open challenges and promising research directions, aiming to chart a roadmap toward building more capable and trustworthy deep research agents.
Tool planning with large language models (LLMs), referring to selecting,
organizing, and preparing the tools necessary to complete a user request,
bridges the gap between natural language understanding and task execution.
However, current works treat different tools as isolated components and fail to
leverage the inherent dependencies of tools, leading to invalid planning
results. Since tool dependencies are often incomplete, it becomes challenging
for LLMs to accurately identify the appropriate tools required by a user
request, especially when confronted with a large toolset. To solve this
challenge, we propose \texttt{GTool}, which is the first work aiming to enhance
the tool planning ability of LLMs under incomplete dependencies. \texttt{GTool}
constructs a request-specific tool graph to select tools efficiently and
generate the \texttt{
This paper introduces RLNVR (Reinforcement Learning from Non-Verified Rewards), a framework for training language models using noisy, real-world feedback signals without requiring explicit human verification. Traditional RLHF requires expensive, verified reward signals that are impractical in many real-world domains. RLNVR addresses this challenge through baseline normalization and semantic similarity-based reward transfer. We demonstrate RLNVR through Walter, a prototype system that optimizes social media content generation using actual engagement data from Bluesky. Our experimental results show significant improvements in content quality and training stability, with comprehensive evaluation planned for future work. Positioning: We present a practical framework that combines RLNVR with GSPO (Group Sequence Policy Optimization) and an optional UED (Unsupervised Environment Design) curriculum to improve stability and diversity under noisy, implicit rewards. To our knowledge, combining GSPO-style normalization with a UED-style curriculum for LLM content generation from implicit social engagement has not been previously documented in this applied setting; we frame this as an applied integration rather than a new algorithm.
The surge in multimodal single-cell omics data exposes limitations in traditional, manually defined analysis workflows. AI agents offer a paradigm shift, enabling adaptive planning, executable code generation, traceable decisions, and real-time knowledge fusion. However, the lack of a comprehensive benchmark critically hinders progress. We introduce a novel benchmarking evaluation system to rigorously assess agent capabilities in single-cell omics analysis. This system comprises: a unified platform compatible with diverse agent frameworks and LLMs; multidimensional metrics assessing cognitive program synthesis, collaboration, execution efficiency, bioinformatics knowledge integration, and task completion quality; and 50 diverse real-world single-cell omics analysis tasks spanning multi-omics, species, and sequencing technologies. Our evaluation reveals that Grok-3-beta achieves state-of-the-art performance among tested agent frameworks. Multi-agent frameworks significantly enhance collaboration and execution efficiency over single-agent approaches through specialized role division. Attribution analyses of agent capabilities identify that high-quality code generation is crucial for task success, and self-reflection has the most significant overall impact, followed by retrieval-augmented generation (RAG) and planning. This work highlights persistent challenges in code generation, long-context handling, and context-aware knowledge retrieval, providing a critical empirical foundation and best practices for developing robust AI agents in computational biology.
Large language model (LLM) agent evaluators leverage specialized tools to ground the rational decision-making of LLMs, making them well-suited to aid in scientific discoveries, such as constrained retrosynthesis planning. Constrained retrosynthesis planning is an essential, yet challenging, process within chemistry for identifying synthetic routes from commercially available starting materials to desired target molecules, subject to practical constraints. Here, we present LARC, the first LLM-based Agentic framework for Retrosynthesis planning under Constraints. LARC incorporates agentic constraint evaluation, through an Agent-as-a-Judge, directly into the retrosynthesis planning process, using agentic feedback grounded in tool-based reasoning to guide and constrain route generation. We rigorously evaluate LARC on a carefully curated set of 48 constrained retrosynthesis planning tasks across 3 constraint types. LARC achieves a 72.9% success rate on these tasks, vastly outperforming LLM baselines and approaching human expert-level success in substantially less time. The LARC framework is extensible, and serves as a first step towards an effective agentic tool or a co-scientist to human experts for constrained retrosynthesis.
In this paper, we present our approach for the CLEF 2025 SimpleText Task 1, which addresses both sentence-level and document-level scientific text simplification. For sentence-level simplification, our methodology employs large language models (LLMs) to first generate a structured plan, followed by plan-driven simplification of individual sentences. At the document level, we leverage LLMs to produce concise summaries and subsequently guide the simplification process using these summaries. This two-stage, LLM-based framework enables more coherent and contextually faithful simplifications of scientific text.
Addressing large-scale planning problems has become one of the central challenges in the planning community, deriving from the state-space explosion caused by growing objects and actions. Recently, researchers have explored the effectiveness of leveraging Large Language Models (LLMs) to generate helpful actions and states to prune the search space. However, prior works have largely overlooked integrating LLMs with domain-specific knowledge to ensure valid plans. In this paper, we propose a novel LLM-assisted planner integrated with problem decomposition, which first decomposes large planning problems into multiple simpler sub-tasks. Then we explore two novel paradigms to utilize LLMs, i.e., LLM4Inspire and LLM4Predict, to assist problem decomposition, where LLM4Inspire provides heuristic guidance according to general knowledge and LLM4Predict employs domain-specific knowledge to infer intermediate conditions. We empirically validate the effectiveness of our planner across multiple domains, demonstrating the ability of search space partition when solving large-scale planning problems. The experimental results show that LLMs effectively locate feasible solutions when pruning the search space, where infusing domain-specific knowledge into LLMs, i.e., LLM4Predict, holds particular promise compared with LLM4Inspire, which offers general knowledge within LLMs.
Automated humor generation with Large Language Models (LLMs) often yields jokes that feel generic, repetitive, or tone-deaf because humor is deeply situated and hinges on the listener's cultural background, mindset, and immediate context. We introduce HumorPlanSearch, a modular pipeline that explicitly models context through: (1) Plan-Search for diverse, topic-tailored strategies; (2) Humor Chain-of-Thought (HuCoT) templates capturing cultural and stylistic reasoning; (3) a Knowledge Graph to retrieve and adapt high-performing historical strategies; (4) novelty filtering via semantic embeddings; and (5) an iterative judge-driven revision loop. To evaluate context sensitivity and comedic quality, we propose the Humor Generation Score (HGS), which fuses direct ratings, multi-persona feedback, pairwise win-rates, and topic relevance. In experiments across nine topics with feedback from 13 human judges, our full pipeline (KG + Revision) boosts mean HGS by 15.4 percent (p < 0.05) over a strong baseline. By foregrounding context at every stage from strategy planning to multi-signal evaluation, HumorPlanSearch advances AI-driven humor toward more coherent, adaptive, and culturally attuned comedy.
Recent advances in mathematical reasoning and the long-term planning capabilities of large language models (LLMs) have precipitated the development of agents, which are being increasingly leveraged in business operations processes. Decision models to optimize inventory levels are one of the core elements of operations management. However, the capabilities of the LLM agent in making inventory decisions in uncertain contexts, as well as the decision-making biases (e.g. framing effect, etc.) of the agent, remain largely unexplored. This prompts concerns regarding the capacity of LLM agents to effectively address real-world problems, as well as the potential implications of biases that may be present. To address this gap, we introduce AIM-Bench, a novel benchmark designed to assess the decision-making behaviour of LLM agents in uncertain supply chain management scenarios through a diverse series of inventory replenishment experiments. Our results reveal that different LLMs typically exhibit varying degrees of decision bias that are similar to those observed in human beings. In addition, we explored strategies to mitigate the pull-to-centre effect and the bullwhip effect, namely cognitive reflection and implementation of information sharing. These findings underscore the need for careful consideration of the potential biases in deploying LLMs in Inventory decision-making scenarios. We hope that these insights will pave the way for mitigating human decision bias and developing human-centred decision support systems for supply chains.
LLM-based agents have emerged as transformative tools capable of executing complex tasks through iterative planning and action, achieving significant advancements in understanding and addressing user needs. Yet, their effectiveness remains limited in specialized domains such as mental health diagnosis, where they underperform compared to general applications. Current approaches to integrating diagnostic capabilities into LLMs rely on scarce, highly sensitive mental health datasets, which are challenging to acquire. These methods also fail to emulate clinicians' proactive inquiry skills, lack multi-turn conversational comprehension, and struggle to align outputs with expert clinical reasoning. To address these gaps, we propose DSM5AgentFlow, the first LLM-based agent workflow designed to autonomously generate DSM-5 Level-1 diagnostic questionnaires. By simulating therapist-client dialogues with specific client profiles, the framework delivers transparent, step-by-step disorder predictions, producing explainable and trustworthy results. This workflow serves as a complementary tool for mental health diagnosis, ensuring adherence to ethical and legal standards. Through comprehensive experiments, we evaluate leading LLMs across three critical dimensions: conversational realism, diagnostic accuracy, and explainability. Our datasets and implementations are fully open-sourced.
AI agentic programming is an emerging paradigm in which large language models (LLMs) autonomously plan, execute, and interact with external tools like compilers, debuggers, and version control systems to iteratively perform complex software development tasks. Unlike conventional code generation tools, agentic systems are capable of decomposing high-level goals, coordinating multi-step processes, and adapting their behavior based on intermediate feedback. These capabilities are transforming the software development practice. As this emerging field evolves rapidly, there is a need to define its scope, consolidate its technical foundations, and identify open research challenges. This survey provides a comprehensive and timely review of AI agentic programming. We introduce a taxonomy of agent behaviors and system architectures, and examine core techniques including planning, memory and context management, tool integration, and execution monitoring. We also analyze existing benchmarks and evaluation methodologies used to assess coding agent performance. Our study identifies several key challenges, including limitations in handling long context, a lack of persistent memory across tasks, and concerns around safety, alignment with user intent, and collaboration with human developers. We discuss emerging opportunities to improve the reliability, adaptability, and transparency of agentic systems. By synthesizing recent advances and outlining future directions, this survey aims to provide a foundation for research and development in building the next generation of intelligent and trustworthy AI coding agents.
Recent advances in large language models (LLMs) enabled the development of AI agents that can plan and interact with tools to complete complex tasks. However, literature on their reliability in real-world applications remains limited. In this paper, we introduce a multi-agent framework for a marketing task: audience curation. To solve this, we introduce a framework called RAMP that iteratively plans, calls tools, verifies the output, and generates suggestions to improve the quality of the audience generated. Additionally, we equip the model with a long-term memory store, which is a knowledge base of client-specific facts and past queries. Overall, we demonstrate the use of LLM planning and memory, which increases accuracy by 28 percentage points on a set of 88 evaluation queries. Moreover, we show the impact of iterative verification and reflection on more ambiguous queries, showing progressively better recall (roughly +20 percentage points) with more verify/reflect iterations on a smaller challenge set, and higher user satisfaction. Our results provide practical insights for deploying reliable LLM-based systems in dynamic, industry-facing environments.
Proton PBS treatment planning for H&N cancers involves numerous conflicting objectives, requiring significant effort from human planners to balance and satisfy multiple clinical goals during planning. To achieve this, experience-demanding objective parameter adjustment and computationally expensive inverse optimization are performed iteratively. Extensive efforts have been made to automatically adjust objective parameters, but the most time-consuming component, i.e., inverse optimization, still relies heavily on theory-driven approaches. We propose a data-driven inverse optimizer and integrate it into a PPO-based automatic treatment planning framework to automatically generate high-quality plans within a clinical acceptable planning time. The inverse optimizer is a L2O method that predicts update steps by learning from the task-specific data distribution. For the first time, we integrate techniques designed for long-context processing, originally developed for LLMs, into a Transformer-based L2O framework to address the scalability issue of existing L2O methods. The PPO framework functions as an outer-loop virtual planner, autonomously adjusting objective parameters through a policy network, and the dose predictor is used to initialize objective parameters. The inner-loop L2O inverse optimizer computes machine-deliverable MU values based on objectives refined by the PPO policy network. 97 patients are collected in this study, and compared with L-BFGSB, our L2O-based inverse optimizer improves the effectiveness and efficiency by 22.97% and 36.41%, respectively. In conjunction with the PPO-based learned virtual planner, plans generated by our framework within an average of 2.55 hours show improved or comparable OAR sparing with superior target coverage for patients with different prescription dose levels, number of target volumes, beam angles, etc., compared with human-generated plans.
Entrepreneurship requires navigating open-ended, ill-defined problems: identifying risks, challenging assumptions, and making strategic decisions under deep uncertainty. Novice founders often struggle with these metacognitive demands, while mentors face limited time and visibility to provide tailored support. We present a human-AI coaching system that combines a domain-specific cognitive model of entrepreneurial risk with a large language model (LLM) to proactively scaffold both novice and mentor thinking. The system proactively poses diagnostic questions that challenge novices' thinking and helps both novices and mentors plan for more focused and emotionally attuned meetings. Critically, mentors can inspect and modify the underlying cognitive model, shaping the logic of the system to reflect their evolving needs. Through an exploratory field deployment, we found that using the system supported novice metacognition, helped mentors plan emotionally attuned strategies, and improved meeting depth, intentionality, and focus--while also surfaced key tensions around trust, misdiagnosis, and expectations of AI. We contribute design principles for proactive AI systems that scaffold metacognition and human-human collaboration in complex, ill-defined domains, offering implications for similar domains like healthcare, education, and knowledge work.
Accurate differentiation of brain tumor types on magnetic resonance imaging (MRI) is critical for guiding treatment planning in neuro-oncology. Recent advances in large language models (LLMs) have enabled visual question answering (VQA) approaches that integrate image interpretation with natural language reasoning. In this study, we evaluated GPT-4o, GPT-5-nano, GPT-5-mini, and GPT-5 on a curated brain tumor VQA benchmark derived from 3 Brain Tumor Segmentation (BraTS) datasets - glioblastoma (GLI), meningioma (MEN), and brain metastases (MET). Each case included multi-sequence MRI triplanar mosaics and structured clinical features transformed into standardized VQA items. Models were assessed in a zero-shot chain-of-thought setting for accuracy on both visual and reasoning tasks. Results showed that GPT-5-mini achieved the highest macro-average accuracy (44.19%), followed by GPT-5 (43.71%), GPT-4o (41.49%), and GPT-5-nano (35.85%). Performance varied by tumor subtype, with no single model dominating across all cohorts. These findings suggest that GPT-5 family models can achieve moderate accuracy in structured neuro-oncological VQA tasks, but not at a level acceptable for clinical use.
Real-world multimodal applications often require any-to-any capabilities, enabling both understanding and generation across modalities including text, image, audio, and video. However, integrating the strengths of autoregressive language models (LLMs) for reasoning and diffusion models for high-fidelity generation remains challenging. Existing approaches rely on rigid pipelines or tightly coupled architectures, limiting flexibility and scalability. We propose MAGUS (Multi-Agent Guided Unified Multimodal System), a modular framework that unifies multimodal understanding and generation via two decoupled phases: Cognition and Deliberation. MAGUS enables symbolic multi-agent collaboration within a shared textual workspace. In the Cognition phase, three role-conditioned multimodal LLM agents - Perceiver, Planner, and Reflector - engage in collaborative dialogue to perform structured understanding and planning. The Deliberation phase incorporates a Growth-Aware Search mechanism that orchestrates LLM-based reasoning and diffusion-based generation in a mutually reinforcing manner. MAGUS supports plug-and-play extensibility, scalable any-to-any modality conversion, and semantic alignment - all without the need for joint training. Experiments across multiple benchmarks, including image, video, and audio generation, as well as cross-modal instruction following, demonstrate that MAGUS outperforms strong baselines and state-of-the-art systems. Notably, on the MME benchmark, MAGUS surpasses the powerful closed-source model GPT-4o.
Evaluating large language models (LLMs) in complex decision-making is essential for advancing AI's ability for strategic planning and real-time adaptation. However, existing benchmarks for tasks like StarCraft II fail to capture the game's full complexity, such as its complete game context, diverse action spaces, and all playable races. To address this gap, we present SC2Arena, a benchmark that fully supports all playable races, low-level action spaces, and optimizes text-based observations to tackle spatial reasoning challenges. Complementing this, we introduce StarEvolve, a hierarchical framework that integrates strategic planning with tactical execution, featuring iterative self-correction and continuous improvement via fine-tuning on high-quality gameplay data. Its key components include a Planner-Executor-Verifier structure to break down gameplay, and a scoring system for selecting high-quality training samples. Comprehensive analysis using SC2Arena provides valuable insights into developing generalist agents that were not possible with previous benchmarks. Experimental results also demonstrate that our proposed StarEvolve achieves superior performance in strategic planning. Our code, environment, and algorithms are publicly available.